Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes
Cell microenvironment has a critical role determining cell fate and modulating cell responses to injuries. Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan that can be considered a signaling molecule. In fact, interacting with several cell surface receptors can deeply shape cel...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/167283 |
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| author | Paola Moretto Evgenia Karousou Manuela Viola Ilaria Caon Maria Luisa D’Angelo Giancarlo De Luca Alberto Passi Davide Vigetti |
| author_facet | Paola Moretto Evgenia Karousou Manuela Viola Ilaria Caon Maria Luisa D’Angelo Giancarlo De Luca Alberto Passi Davide Vigetti |
| author_sort | Paola Moretto |
| collection | DOAJ |
| description | Cell microenvironment has a critical role determining cell fate and modulating cell responses to injuries. Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan that can be considered a signaling molecule. In fact, interacting with several cell surface receptors can deeply shape cell behavior. In vascular biology, HA triggers smooth muscle cells (SMCs) dedifferentiation which contributes to vessel wall thickening. Furthermore, HA is able to modulate inflammation by altering the adhesive properties of endothelial cells. In hyperglycemic conditions, HA accumulates in vessels and can contribute to the diabetic complications at micro- and macrovasculature. Due to the pivotal role in favoring atherogenesis and neointima formation after injuries, HA could be a new target for cardiovascular pathologies. This review will focus on the recent findings regarding the regulation of HA synthesis in human vascular SMCs. In particular, the effects of the intracellular HA substrates availability, adenosine monophosphate-activated protein kinase (AMPK), and protein O-GlcNAcylation on the main HA synthetic enzyme (i.e., HAS2) will be discussed. |
| format | Article |
| id | doaj-art-5a3299cc9ac44e0385f1231c3fa8a6c9 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5a3299cc9ac44e0385f1231c3fa8a6c92025-08-20T03:34:13ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/167283167283Regulation of Hyaluronan Synthesis in Vascular Diseases and DiabetesPaola Moretto0Evgenia Karousou1Manuela Viola2Ilaria Caon3Maria Luisa D’Angelo4Giancarlo De Luca5Alberto Passi6Davide Vigetti7Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, ItalyCell microenvironment has a critical role determining cell fate and modulating cell responses to injuries. Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan that can be considered a signaling molecule. In fact, interacting with several cell surface receptors can deeply shape cell behavior. In vascular biology, HA triggers smooth muscle cells (SMCs) dedifferentiation which contributes to vessel wall thickening. Furthermore, HA is able to modulate inflammation by altering the adhesive properties of endothelial cells. In hyperglycemic conditions, HA accumulates in vessels and can contribute to the diabetic complications at micro- and macrovasculature. Due to the pivotal role in favoring atherogenesis and neointima formation after injuries, HA could be a new target for cardiovascular pathologies. This review will focus on the recent findings regarding the regulation of HA synthesis in human vascular SMCs. In particular, the effects of the intracellular HA substrates availability, adenosine monophosphate-activated protein kinase (AMPK), and protein O-GlcNAcylation on the main HA synthetic enzyme (i.e., HAS2) will be discussed.http://dx.doi.org/10.1155/2015/167283 |
| spellingShingle | Paola Moretto Evgenia Karousou Manuela Viola Ilaria Caon Maria Luisa D’Angelo Giancarlo De Luca Alberto Passi Davide Vigetti Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes Journal of Diabetes Research |
| title | Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes |
| title_full | Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes |
| title_fullStr | Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes |
| title_full_unstemmed | Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes |
| title_short | Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes |
| title_sort | regulation of hyaluronan synthesis in vascular diseases and diabetes |
| url | http://dx.doi.org/10.1155/2015/167283 |
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