Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis
Fibroblasts have been implicated in psoriatic inflammatory processes. The aim of the study was to evaluate soluble interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6 and IL-8 levels in fibroblast culture supernatants. Cytokine...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/81767 |
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| _version_ | 1850225018680639488 |
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| author | Anna Zalewska Ewa Głowacka Janina Wyczółkowska Henryk Tchórzewski Joanna Narbutt Anna Sysa-Jȩdrzejowska |
| author_facet | Anna Zalewska Ewa Głowacka Janina Wyczółkowska Henryk Tchórzewski Joanna Narbutt Anna Sysa-Jȩdrzejowska |
| author_sort | Anna Zalewska |
| collection | DOAJ |
| description | Fibroblasts have been implicated in psoriatic inflammatory
processes. The aim of the study was to evaluate soluble
interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and
interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6
and IL-8 levels in fibroblast culture supernatants. Cytokines
levels in plasma and supernatants were measured by ELISA. Plasma
sIL-2R, IL-6, and IL-8 levels were higher before the treatment in
comparison to healthy controls (P<0.001) and decreased after
treatment. Fibroblasts from healthy controls, psoriatic lesional
skin, and noninvolved psoriatic skin, when stimulated with tumor
necrosis factor alpha, released considerable amounts of IL-6 and
IL-8. No significant difference between healthy controls and
psoriatic fibroblasts was observed. Monitoring plasma sIL-2R
levels could be employed as a reliable method of psoriasis
activity. IL-8 and IL-6 plasma levels seem to reflect psoriasis
activity, and treatment response, respectively. Fibroblasts are
not a major source of increased IL-6 and IL-8 production in
psoriasis. |
| format | Article |
| id | doaj-art-5a2925b155c44f49b7e35cf9ec7b5bbd |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5a2925b155c44f49b7e35cf9ec7b5bbd2025-08-20T02:05:29ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/8176781767Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in PsoriasisAnna Zalewska0Ewa Głowacka1Janina Wyczółkowska2Henryk Tchórzewski3Joanna Narbutt4Anna Sysa-Jȩdrzejowska5Department of Dermatology and Venereology, Medical University of Łódź, 5 Krzemieniecka Street, Łódź 94-017, PolandDepartment of Clinical Immunology, Polish Mother’s Memorial Hospital-Research Institute, 93-338 Łódź, PolandCentre for Medical Biology, Polish Academy of Sciences, Łódź 93-232, PolandDepartment of Clinical Immunology, Polish Mother’s Memorial Hospital-Research Institute, 93-338 Łódź, PolandDepartment of Dermatology and Venereology, Medical University of Łódź, 5 Krzemieniecka Street, Łódź 94-017, PolandDepartment of Dermatology and Venereology, Medical University of Łódź, 5 Krzemieniecka Street, Łódź 94-017, PolandFibroblasts have been implicated in psoriatic inflammatory processes. The aim of the study was to evaluate soluble interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6 and IL-8 levels in fibroblast culture supernatants. Cytokines levels in plasma and supernatants were measured by ELISA. Plasma sIL-2R, IL-6, and IL-8 levels were higher before the treatment in comparison to healthy controls (P<0.001) and decreased after treatment. Fibroblasts from healthy controls, psoriatic lesional skin, and noninvolved psoriatic skin, when stimulated with tumor necrosis factor alpha, released considerable amounts of IL-6 and IL-8. No significant difference between healthy controls and psoriatic fibroblasts was observed. Monitoring plasma sIL-2R levels could be employed as a reliable method of psoriasis activity. IL-8 and IL-6 plasma levels seem to reflect psoriasis activity, and treatment response, respectively. Fibroblasts are not a major source of increased IL-6 and IL-8 production in psoriasis.http://dx.doi.org/10.1155/MI/2006/81767 |
| spellingShingle | Anna Zalewska Ewa Głowacka Janina Wyczółkowska Henryk Tchórzewski Joanna Narbutt Anna Sysa-Jȩdrzejowska Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis Mediators of Inflammation |
| title | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_full | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_fullStr | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_full_unstemmed | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_short | Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis |
| title_sort | interleukin 6 and 8 levels in plasma and fibroblast cultures in psoriasis |
| url | http://dx.doi.org/10.1155/MI/2006/81767 |
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