Interleukin 6 and 8 Levels in Plasma and Fibroblast Cultures in Psoriasis
Fibroblasts have been implicated in psoriatic inflammatory processes. The aim of the study was to evaluate soluble interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6 and IL-8 levels in fibroblast culture supernatants. Cytokine...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/81767 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Fibroblasts have been implicated in psoriatic inflammatory
processes. The aim of the study was to evaluate soluble
interleukin 2 receptor (sIL-2R), interleukin 6 (IL-6), and
interleukin 8 (IL-8) plasma levels in psoriatic patients and IL-6
and IL-8 levels in fibroblast culture supernatants. Cytokines
levels in plasma and supernatants were measured by ELISA. Plasma
sIL-2R, IL-6, and IL-8 levels were higher before the treatment in
comparison to healthy controls (P<0.001) and decreased after
treatment. Fibroblasts from healthy controls, psoriatic lesional
skin, and noninvolved psoriatic skin, when stimulated with tumor
necrosis factor alpha, released considerable amounts of IL-6 and
IL-8. No significant difference between healthy controls and
psoriatic fibroblasts was observed. Monitoring plasma sIL-2R
levels could be employed as a reliable method of psoriasis
activity. IL-8 and IL-6 plasma levels seem to reflect psoriasis
activity, and treatment response, respectively. Fibroblasts are
not a major source of increased IL-6 and IL-8 production in
psoriasis. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |