Canagliflozin‐induced renal glutathione distribution mapping in non‐diabetic male rat kidneys

Abstract Canagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, has direct renoprotective effects beyond lowering blood glucose levels. The inhibition of sodium reabsorption via SGLT2 reduces the overload on proximal tubules, thereby suppressing the generation of reactive oxygen species...

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Bibliographic Details
Main Authors: Guy Watanabe, Shoichiro Horita, Reika Flora Moriya, Yusuke Masuishi, Shingen Misaka, Shu Taira, Kenju Shimomura, Michio Shimabukuro, Junichiro James Kazama
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Physiological Reports
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Online Access:https://doi.org/10.14814/phy2.70320
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