Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies
ABSTRACT Background and Aims In Ethiopia, pre‐labor rupture of membranes impacts maternal and perinatal health, while maternal undernutrition remains a major public health issue. The findings of previous studies have been inconsistent, and no nationwide pooled data exist. Therefore, this review aims...
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2025-06-01
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| Online Access: | https://doi.org/10.1002/hsr2.70901 |
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| author | Ebrahim Msaye Assefa Hussen Abdu Altaseb Beyene Kassaw Mekonnen Belete Amare Abera Tareke Addis Alem Mohammed Derso Bihonegn Abdulaziz Kebede Kassaw Ahmed Juhar Temam Gashaw Abebe Melese Shenkut Abebe Gosa Mankelkl Zeleke Geto Seid Mohammed Abdu |
| author_facet | Ebrahim Msaye Assefa Hussen Abdu Altaseb Beyene Kassaw Mekonnen Belete Amare Abera Tareke Addis Alem Mohammed Derso Bihonegn Abdulaziz Kebede Kassaw Ahmed Juhar Temam Gashaw Abebe Melese Shenkut Abebe Gosa Mankelkl Zeleke Geto Seid Mohammed Abdu |
| author_sort | Ebrahim Msaye Assefa |
| collection | DOAJ |
| description | ABSTRACT Background and Aims In Ethiopia, pre‐labor rupture of membranes impacts maternal and perinatal health, while maternal undernutrition remains a major public health issue. The findings of previous studies have been inconsistent, and no nationwide pooled data exist. Therefore, this review aims to investigate the association between maternal undernutrition and pre‐labor rupture of membranes in Ethiopia. Methods Comprehensive and systematic searches were conducted across various databases, including PubMed, Google Scholar, Hinari, and ScienceDirect. The data were extracted using Microsoft Excel and analyzed with STATA version 17. The risk of bias and certainty of the evidence were evaluated. Heterogeneity was assessed using I2 statistics, and a random effects model was employed to estimate the pooled effect size (odds ratio) with a 95% CI. A funnel plot and Egger's test were also used to assess potential publication bias. Results A total of twelve observational studies, involving 4016 participants, were included in this systematic review and meta‐analysis. Most studies showed a low risk of bias and a moderate level of certainty in the evidence. The pooled results indicated a significant association between maternal undernutrition and pre‐labor rupture of membranes in Ethiopia (pooled OR = 3.24; 95% CI: 2.08–5.06), with substantial heterogeneity (I2 = 74.9%, p < 0.001). Sensitivity analysis confirmed the stability of the pooled estimates, and no publication bias was detected. Conclusion This meta‐analysis shows a significant association between maternal undernutrition and an increased risk of pre‐labor rupture of membranes in Ethiopia. Therefore, health institutions should assess the nutritional status of pregnant women during prenatal visits for counseling and supplementation programs. Policymakers need to develop public health policies to address maternal nutrition. We recommend further research that explore the role of specific nutrient deficiencies in pre‐labor rupture of membranes. Review Registration ID PROSPERO CRD42024579002. |
| format | Article |
| id | doaj-art-5a1e2aabae024c1e9f7319ae1ad7b5a0 |
| institution | OA Journals |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-5a1e2aabae024c1e9f7319ae1ad7b5a02025-08-20T02:35:07ZengWileyHealth Science Reports2398-88352025-06-0186n/an/a10.1002/hsr2.70901Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational StudiesEbrahim Msaye Assefa0Hussen Abdu1Altaseb Beyene Kassaw2Mekonnen Belete3Amare Abera Tareke4Addis Alem5Mohammed Derso Bihonegn6Abdulaziz Kebede Kassaw7Ahmed Juhar Temam8Gashaw Abebe9Melese Shenkut Abebe10Gosa Mankelkl11Zeleke Geto12Seid Mohammed Abdu13Department of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Health Informatics, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaDepartment of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences Wollo University Dessie EthiopiaABSTRACT Background and Aims In Ethiopia, pre‐labor rupture of membranes impacts maternal and perinatal health, while maternal undernutrition remains a major public health issue. The findings of previous studies have been inconsistent, and no nationwide pooled data exist. Therefore, this review aims to investigate the association between maternal undernutrition and pre‐labor rupture of membranes in Ethiopia. Methods Comprehensive and systematic searches were conducted across various databases, including PubMed, Google Scholar, Hinari, and ScienceDirect. The data were extracted using Microsoft Excel and analyzed with STATA version 17. The risk of bias and certainty of the evidence were evaluated. Heterogeneity was assessed using I2 statistics, and a random effects model was employed to estimate the pooled effect size (odds ratio) with a 95% CI. A funnel plot and Egger's test were also used to assess potential publication bias. Results A total of twelve observational studies, involving 4016 participants, were included in this systematic review and meta‐analysis. Most studies showed a low risk of bias and a moderate level of certainty in the evidence. The pooled results indicated a significant association between maternal undernutrition and pre‐labor rupture of membranes in Ethiopia (pooled OR = 3.24; 95% CI: 2.08–5.06), with substantial heterogeneity (I2 = 74.9%, p < 0.001). Sensitivity analysis confirmed the stability of the pooled estimates, and no publication bias was detected. Conclusion This meta‐analysis shows a significant association between maternal undernutrition and an increased risk of pre‐labor rupture of membranes in Ethiopia. Therefore, health institutions should assess the nutritional status of pregnant women during prenatal visits for counseling and supplementation programs. Policymakers need to develop public health policies to address maternal nutrition. We recommend further research that explore the role of specific nutrient deficiencies in pre‐labor rupture of membranes. Review Registration ID PROSPERO CRD42024579002.https://doi.org/10.1002/hsr2.70901ethiopiamaternal undernutritionmeta‐analysispre‐labor rupture of membranessystematic review |
| spellingShingle | Ebrahim Msaye Assefa Hussen Abdu Altaseb Beyene Kassaw Mekonnen Belete Amare Abera Tareke Addis Alem Mohammed Derso Bihonegn Abdulaziz Kebede Kassaw Ahmed Juhar Temam Gashaw Abebe Melese Shenkut Abebe Gosa Mankelkl Zeleke Geto Seid Mohammed Abdu Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies Health Science Reports ethiopia maternal undernutrition meta‐analysis pre‐labor rupture of membranes systematic review |
| title | Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies |
| title_full | Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies |
| title_fullStr | Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies |
| title_full_unstemmed | Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies |
| title_short | Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies |
| title_sort | association between maternal undernutrition and pre labor rupture of membranes in ethiopia a systematic review and meta analysis of observational studies |
| topic | ethiopia maternal undernutrition meta‐analysis pre‐labor rupture of membranes systematic review |
| url | https://doi.org/10.1002/hsr2.70901 |
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