Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.

Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.

The Transforming Growth Factor (TGF) beta signalling family includes morphogens, such as Nodal and Activin, with important functions in vertebrate development. The concentration of the morphogen is critical for fate decisions in the responding cells. Smad2 and Smad3 are effectors of the Nodal/Activi...

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Bibliographic Details
Main Authors: Marcela Guzman-Ayala, Kian Leong Lee, Konstantinos J Mavrakis, Paraskevi Goggolidou, Dominic P Norris, Vasso Episkopou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004268&type=printable
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