Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy
Abstract This study aims to investigate associations between PM10, PM2.5, and NO2 and maternal thyroid hormones. We investigated 443 pregnant women in Zhejiang, China with repeated examinations of serum thyroid hormones at 10, 17, and 32 weeks. Individual exposures to ambient air pollution were retr...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-09126-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849334760560656384 |
|---|---|
| author | Fanjia Guo Xinhui Pan Simeng Gu Qinghua Xu Jiafu Duan Xiaofeng Wang Zhijian Chen Qiuli Fu Guangming Mao Peiwei Xu Dandan Xu Xuemin Huang Yahui Li Yujie Jiang Chenyang Liu Zhe Mo |
| author_facet | Fanjia Guo Xinhui Pan Simeng Gu Qinghua Xu Jiafu Duan Xiaofeng Wang Zhijian Chen Qiuli Fu Guangming Mao Peiwei Xu Dandan Xu Xuemin Huang Yahui Li Yujie Jiang Chenyang Liu Zhe Mo |
| author_sort | Fanjia Guo |
| collection | DOAJ |
| description | Abstract This study aims to investigate associations between PM10, PM2.5, and NO2 and maternal thyroid hormones. We investigated 443 pregnant women in Zhejiang, China with repeated examinations of serum thyroid hormones at 10, 17, and 32 weeks. Individual exposures to ambient air pollution were retrospectively calculated by inverse distance weighting interpolation. Multivariate linear mixed models were applied to estimate the association between air pollutants and thyroid hormones. PM10 exposure was positively associated with TSH (β: 0.077 [95% CI: 0.003, 0.152]), and negatively associated with FT3 (β: -0.041 [-0.057, -0.025]) and FT4 (β: -0.036 [-0.055, -0.017]) during the 0–90 lag days (per IQR). Similarly, increased exposure to PM2.5 was associated with decreased FT3 (β: -0.016 [-0.032, -0.001]), and increased Tg (β: 0.147 [0.025, 0.269]). Evaluated NO2 levels were associated with decreased FT3 (β: -0.026 [-0.039, -0.014]) and FT4 (β: -0.036 [-0.052, -0.020]), as well as increased Tg (β: 0.129 [0.011, 0.247]). The results indicate that exposure to ambient PM10, PM2.5, and NO2 throughout the entire pregnancy adversely affects thyroid hormones, implying potential health implications of air pollution on maternal thyroid function. |
| format | Article |
| id | doaj-art-5a15195ade9544239432d66c021d5a3f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-5a15195ade9544239432d66c021d5a3f2025-08-20T03:45:28ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-09126-4Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancyFanjia Guo0Xinhui Pan1Simeng Gu2Qinghua Xu3Jiafu Duan4Xiaofeng Wang5Zhijian Chen6Qiuli Fu7Guangming Mao8Peiwei Xu9Dandan Xu10Xuemin Huang11Yahui Li12Yujie Jiang13Chenyang Liu14Zhe Mo15Department of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionChangshan Center for Disease Control and PreventionChangshan Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionEye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye DiseasesDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and PreventionAbstract This study aims to investigate associations between PM10, PM2.5, and NO2 and maternal thyroid hormones. We investigated 443 pregnant women in Zhejiang, China with repeated examinations of serum thyroid hormones at 10, 17, and 32 weeks. Individual exposures to ambient air pollution were retrospectively calculated by inverse distance weighting interpolation. Multivariate linear mixed models were applied to estimate the association between air pollutants and thyroid hormones. PM10 exposure was positively associated with TSH (β: 0.077 [95% CI: 0.003, 0.152]), and negatively associated with FT3 (β: -0.041 [-0.057, -0.025]) and FT4 (β: -0.036 [-0.055, -0.017]) during the 0–90 lag days (per IQR). Similarly, increased exposure to PM2.5 was associated with decreased FT3 (β: -0.016 [-0.032, -0.001]), and increased Tg (β: 0.147 [0.025, 0.269]). Evaluated NO2 levels were associated with decreased FT3 (β: -0.026 [-0.039, -0.014]) and FT4 (β: -0.036 [-0.052, -0.020]), as well as increased Tg (β: 0.129 [0.011, 0.247]). The results indicate that exposure to ambient PM10, PM2.5, and NO2 throughout the entire pregnancy adversely affects thyroid hormones, implying potential health implications of air pollution on maternal thyroid function.https://doi.org/10.1038/s41598-025-09126-4Thyroid hormonesAir pollutionInverse distance weightingMaternal thyroid functionPregnancy |
| spellingShingle | Fanjia Guo Xinhui Pan Simeng Gu Qinghua Xu Jiafu Duan Xiaofeng Wang Zhijian Chen Qiuli Fu Guangming Mao Peiwei Xu Dandan Xu Xuemin Huang Yahui Li Yujie Jiang Chenyang Liu Zhe Mo Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy Scientific Reports Thyroid hormones Air pollution Inverse distance weighting Maternal thyroid function Pregnancy |
| title | Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy |
| title_full | Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy |
| title_fullStr | Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy |
| title_full_unstemmed | Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy |
| title_short | Association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy |
| title_sort | association of ambient air pollutants with maternal thyroid hormones during the entire pregnancy |
| topic | Thyroid hormones Air pollution Inverse distance weighting Maternal thyroid function Pregnancy |
| url | https://doi.org/10.1038/s41598-025-09126-4 |
| work_keys_str_mv | AT fanjiaguo associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT xinhuipan associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT simenggu associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT qinghuaxu associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT jiafuduan associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT xiaofengwang associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT zhijianchen associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT qiulifu associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT guangmingmao associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT peiweixu associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT dandanxu associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT xueminhuang associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT yahuili associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT yujiejiang associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT chenyangliu associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy AT zhemo associationofambientairpollutantswithmaternalthyroidhormonesduringtheentirepregnancy |