Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature review
Abstract Background A considerable number of patients with deep vein thrombosis of the lower extremities will develop post-thrombotic syndrome even after receiving standardized anticoagulation therapy. Damage to the femoral vein valves caused by post-thrombotic syndrome can lead to severe chronic lo...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Thrombosis Journal |
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| Online Access: | https://doi.org/10.1186/s12959-025-00752-6 |
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| author | Dafang Liu Hui Zhao Jie Zhang Liang Zhao Yingfeng Wu |
| author_facet | Dafang Liu Hui Zhao Jie Zhang Liang Zhao Yingfeng Wu |
| author_sort | Dafang Liu |
| collection | DOAJ |
| description | Abstract Background A considerable number of patients with deep vein thrombosis of the lower extremities will develop post-thrombotic syndrome even after receiving standardized anticoagulation therapy. Damage to the femoral vein valves caused by post-thrombotic syndrome can lead to severe chronic lower limb venous insufficiency and currently there is a lack of effective treatment. Case presentation We present a patient with pigmentation and itching due to post-thrombotic syndrome, where the anterior leaflet of the first set of valves in the superficial femoral vein was completely destroyed, while the posterior leaflet, although structurally intact, was adhered to the vessel wall. By reconstructing the posterior leaflet of the femoral vein valve and simultaneously narrowing the lumen where the anterior leaflet was located through suture ligation, we restored the valve’s function to prevent venous reflux. During a 12-month follow-up period, the patient’s quality of life significantly improved. Conclusions Single-leaflet reconstruction surgery may serve as a potential treatment option for patients with post-thrombotic syndrome. |
| format | Article |
| id | doaj-art-5a100100d4b24646972bbc052d198d5d |
| institution | Kabale University |
| issn | 1477-9560 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj-art-5a100100d4b24646972bbc052d198d5d2025-08-20T03:47:16ZengBMCThrombosis Journal1477-95602025-06-012311710.1186/s12959-025-00752-6Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature reviewDafang Liu0Hui Zhao1Jie Zhang2Liang Zhao3Yingfeng Wu4Department of Vascular Surgery, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Vascular Surgery, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Vascular Surgery, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Vascular Surgery, Beijing Luhe Hospital, Capital Medical UniversityDepartment of Vascular Surgery, Beijing Luhe Hospital, Capital Medical UniversityAbstract Background A considerable number of patients with deep vein thrombosis of the lower extremities will develop post-thrombotic syndrome even after receiving standardized anticoagulation therapy. Damage to the femoral vein valves caused by post-thrombotic syndrome can lead to severe chronic lower limb venous insufficiency and currently there is a lack of effective treatment. Case presentation We present a patient with pigmentation and itching due to post-thrombotic syndrome, where the anterior leaflet of the first set of valves in the superficial femoral vein was completely destroyed, while the posterior leaflet, although structurally intact, was adhered to the vessel wall. By reconstructing the posterior leaflet of the femoral vein valve and simultaneously narrowing the lumen where the anterior leaflet was located through suture ligation, we restored the valve’s function to prevent venous reflux. During a 12-month follow-up period, the patient’s quality of life significantly improved. Conclusions Single-leaflet reconstruction surgery may serve as a potential treatment option for patients with post-thrombotic syndrome.https://doi.org/10.1186/s12959-025-00752-6Deep vein thrombosisPost-thrombotic syndromeChronic venous insufficiencyFemoral veinValvuloplasty |
| spellingShingle | Dafang Liu Hui Zhao Jie Zhang Liang Zhao Yingfeng Wu Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature review Thrombosis Journal Deep vein thrombosis Post-thrombotic syndrome Chronic venous insufficiency Femoral vein Valvuloplasty |
| title | Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature review |
| title_full | Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature review |
| title_fullStr | Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature review |
| title_full_unstemmed | Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature review |
| title_short | Single-leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post-thrombotic syndrome: a case report and literature review |
| title_sort | single leaflet reconstruction surgery for severe chronic lower limb venous insufficiency caused by post thrombotic syndrome a case report and literature review |
| topic | Deep vein thrombosis Post-thrombotic syndrome Chronic venous insufficiency Femoral vein Valvuloplasty |
| url | https://doi.org/10.1186/s12959-025-00752-6 |
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