Anthropometric parameters in patients with ischemic myocardial dilation and CTLA4 rs231775 polymorphisms
BACKGROUND: Ischemic myocardial dilation (IMD) develops as a result of coronary artery disease and may lead to heart failure with significantly reduced cardiac contractility. Previously we identified genetic factors associated with the risk of developing IMD. We found no data in available sources on...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Concilium Medicum
2025-01-01
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| Series: | КардиоСоматика |
| Subjects: | |
| Online Access: | https://cardiosomatics.ru/2221-7185/article/viewFile/678602/204320 |
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| Summary: | BACKGROUND: Ischemic myocardial dilation (IMD) develops as a result of coronary artery disease and may lead to heart failure with significantly reduced cardiac contractility. Previously we identified genetic factors associated with the risk of developing IMD. We found no data in available sources on the association between anthropometric characteristics and IMD.
AIM: The work aimed to identify anthropometric parameters associated with IMD in carriers ща CTLA4 rs231775 polymorphisms.
METHODS: The study included 113 patients with IMD (103 men and 10 women). The control group comprised 101 healthy individuals. Evaluation included history taking, physical examination, measurement of anthropometric parameters, and instrumental investigations including coronary artery assessment. DNA was extracted from venous blood samples using the phenol-chloroform method for subsequent genotyping.
RESULTS: Among patients carrying the GG genotype, the pyknic body type was significantly more frequent compared with controls (64% vs 9.7%; χ2 = 55.557; p 0.001). In IMD groups, the andromorphic body type predominated, whereas the control group predominantly exhibited gynecomorphic and mesomorphic types.
CONCLUSION: The GG genotype of the rs231775 polymorphism in the CTLA4 gene and the pyknic body type are likely associated with IMD. |
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| ISSN: | 2221-7185 2658-5707 |