Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021
Abstract Background Retinoblastoma (RB), an aggressive intraocular malignancy, significantly adds to the global disease burden in early childhood. This study offers insights into the global burden of retinoblastoma (RB) in children aged 0–9 years, examining incidence, mortality, and DALYs from 1990...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12916-024-03827-9 |
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| author | Cong Li Lijun Zhang Jie Zhang Jinghua Jiao Guangyao Hua Yan Wang Xue He Chingyu Cheng Honghua Yu Xiaohong Yang Lei Liu |
| author_facet | Cong Li Lijun Zhang Jie Zhang Jinghua Jiao Guangyao Hua Yan Wang Xue He Chingyu Cheng Honghua Yu Xiaohong Yang Lei Liu |
| author_sort | Cong Li |
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| description | Abstract Background Retinoblastoma (RB), an aggressive intraocular malignancy, significantly adds to the global disease burden in early childhood. This study offers insights into the global burden of retinoblastoma (RB) in children aged 0–9 years, examining incidence, mortality, and DALYs from 1990 to 2021, across age, sex, location, and SDI levels. It aims to inform health policy, resource allocation, and RB combat strategies. Methods Data were retrieved from newly released Global Burden of Disease (GBD) study. The measures were estimated both as numerical counts and age-standardised rates per 100,000 population. Joinpoint regression analysis was used to rigorously examine temporal trends, estimating the average annual percentage change (AAPC). Spearman’s correlation test was used to examine the relationship between SDI and the burden of RB by location and year. Results Globally, the age-standardised incidence rate (ASIR), age-standardised mortality rate (ASMR), and age-standardised DALYs rate (ASDR) for RB among young children in 2021 were 0.09 [95% uncertainty interval (UI): 0.05 to 0.13], 0.04 (95%UI: 0.03 to 0.06), and 3.65 (95%UI: 2.21 to 4.96), respectively. Despite an overall increasing trend in incidence [AAPC: 0.62; 95% confidence interval (CI): 0.42 to 0.82], the RB incidence rate demonstrated a significant decline from 2019 to 2021, while mortality and DALYs rate for RB showed overall downward trends. Trends in ASIR varied across regions, with the highest increase in East Asia. Among all GBD regions, only Southern Sub-Saharan Africa exhibited rising trends in mortality and DALYs rate. Gender comparisons showed negligible differences in ASIR, ASMR and ASDR in 2021. Moreover, the highest disease burden was noted in early neonatal (0–6 days), and in children aged 2–4 years at both global and regional levels. Analysis by SDI indicated that RB incidence rates increased with higher SDI levels. In addition, a significantly negative correlation was found between SDI level and both ASMR and ASDR of RB among children aged 0–9 years. Conclusions From 1990 to 2021, RB-related incidence, mortality, and DALYs varied by age and location. Evaluating spatiotemporal trends underscores the impact of health policies and substantial public health interventions on RB control. |
| format | Article |
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| institution | Kabale University |
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| spelling | doaj-art-5a0a39935579418695b0463ffec3d9b82025-01-05T12:32:53ZengBMCBMC Medicine1741-70152024-12-0122111310.1186/s12916-024-03827-9Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021Cong Li0Lijun Zhang1Jie Zhang2Jinghua Jiao3Guangyao Hua4Yan Wang5Xue He6Chingyu Cheng7Honghua Yu8Xiaohong Yang9Lei Liu10Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityDepartment of Ophthalmology, The Third People’s Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical UniversityDepartment of Ophthalmology, ZhengdaGuangming Ophthalmology Group, National Key Clinical Specialty, Weifang Eye Hospital; Weifang Institute of OphthalmologyDepartment of Anesthesiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical UniversityDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversitySingapore Eye Research Institute, Singapore National Eye CentreGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityAbstract Background Retinoblastoma (RB), an aggressive intraocular malignancy, significantly adds to the global disease burden in early childhood. This study offers insights into the global burden of retinoblastoma (RB) in children aged 0–9 years, examining incidence, mortality, and DALYs from 1990 to 2021, across age, sex, location, and SDI levels. It aims to inform health policy, resource allocation, and RB combat strategies. Methods Data were retrieved from newly released Global Burden of Disease (GBD) study. The measures were estimated both as numerical counts and age-standardised rates per 100,000 population. Joinpoint regression analysis was used to rigorously examine temporal trends, estimating the average annual percentage change (AAPC). Spearman’s correlation test was used to examine the relationship between SDI and the burden of RB by location and year. Results Globally, the age-standardised incidence rate (ASIR), age-standardised mortality rate (ASMR), and age-standardised DALYs rate (ASDR) for RB among young children in 2021 were 0.09 [95% uncertainty interval (UI): 0.05 to 0.13], 0.04 (95%UI: 0.03 to 0.06), and 3.65 (95%UI: 2.21 to 4.96), respectively. Despite an overall increasing trend in incidence [AAPC: 0.62; 95% confidence interval (CI): 0.42 to 0.82], the RB incidence rate demonstrated a significant decline from 2019 to 2021, while mortality and DALYs rate for RB showed overall downward trends. Trends in ASIR varied across regions, with the highest increase in East Asia. Among all GBD regions, only Southern Sub-Saharan Africa exhibited rising trends in mortality and DALYs rate. Gender comparisons showed negligible differences in ASIR, ASMR and ASDR in 2021. Moreover, the highest disease burden was noted in early neonatal (0–6 days), and in children aged 2–4 years at both global and regional levels. Analysis by SDI indicated that RB incidence rates increased with higher SDI levels. In addition, a significantly negative correlation was found between SDI level and both ASMR and ASDR of RB among children aged 0–9 years. Conclusions From 1990 to 2021, RB-related incidence, mortality, and DALYs varied by age and location. Evaluating spatiotemporal trends underscores the impact of health policies and substantial public health interventions on RB control.https://doi.org/10.1186/s12916-024-03827-9RetinoblastomaChildrenGlobal burden of diseaseIncidenceMortalityDisability-adjusted life years |
| spellingShingle | Cong Li Lijun Zhang Jie Zhang Jinghua Jiao Guangyao Hua Yan Wang Xue He Chingyu Cheng Honghua Yu Xiaohong Yang Lei Liu Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 BMC Medicine Retinoblastoma Children Global burden of disease Incidence Mortality Disability-adjusted life years |
| title | Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 |
| title_full | Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 |
| title_fullStr | Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 |
| title_full_unstemmed | Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 |
| title_short | Global, regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 |
| title_sort | global regional and national burden due to retinoblastoma in children aged younger than 10 years from 1990 to 2021 |
| topic | Retinoblastoma Children Global burden of disease Incidence Mortality Disability-adjusted life years |
| url | https://doi.org/10.1186/s12916-024-03827-9 |
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