A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33)
Mixed phenotype acute leukemia (MPAL) is a rare neoplasm which accounts for 2–5% of all leukemias and it is classified under heading of acute leukemia of ambiguous lineage in 2008 WHO classification. This patient was a 61-year-old man who presented with malaise and weakness. In physical examination...
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| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/8937940 |
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| author | Ahmad Monabati Akbar Safaei Sadat Nouri Moeinadin Safavi Freidoon Solhjoo |
| author_facet | Ahmad Monabati Akbar Safaei Sadat Nouri Moeinadin Safavi Freidoon Solhjoo |
| author_sort | Ahmad Monabati |
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| description | Mixed phenotype acute leukemia (MPAL) is a rare neoplasm which accounts for 2–5% of all leukemias and it is classified under heading of acute leukemia of ambiguous lineage in 2008 WHO classification. This patient was a 61-year-old man who presented with malaise and weakness. In physical examination there was cervical and axillary lymphadenopathy. Paraclinical evaluation revealed anemia (Hb = 10.3 g/dL, MCV = 108 fl). Histologic sections of the axillary lymph node revealed leukemic involvement with two discrete populations of cells in immunohistochemistry. One population was immunoreactive for MPO and the other showed immunostaining for CD3, CD99, and tdt. Differential count of bone marrow cells in marrow aspirate had 6% blast. Karyotype study on bone marrow culture depicted an interesting finding which was t(1;5)(q23;q33). An extensive search on literature was done for the same genetic change. A similar translocation has been mentioned in literature for other hematologic malignancies but not for same neoplasm; anyhow this translocation was an imbalanced one and led to der(5)t(1;5)(q12-25;q13-q35). |
| format | Article |
| id | doaj-art-5a0a0489cd084cf7a8e3d4208231aa9b |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Case Reports in Pathology |
| spelling | doaj-art-5a0a0489cd084cf7a8e3d4208231aa9b2025-08-20T02:05:34ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/89379408937940A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33)Ahmad Monabati0Akbar Safaei1Sadat Nouri2Moeinadin Safavi3Freidoon Solhjoo4Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranMixed phenotype acute leukemia (MPAL) is a rare neoplasm which accounts for 2–5% of all leukemias and it is classified under heading of acute leukemia of ambiguous lineage in 2008 WHO classification. This patient was a 61-year-old man who presented with malaise and weakness. In physical examination there was cervical and axillary lymphadenopathy. Paraclinical evaluation revealed anemia (Hb = 10.3 g/dL, MCV = 108 fl). Histologic sections of the axillary lymph node revealed leukemic involvement with two discrete populations of cells in immunohistochemistry. One population was immunoreactive for MPO and the other showed immunostaining for CD3, CD99, and tdt. Differential count of bone marrow cells in marrow aspirate had 6% blast. Karyotype study on bone marrow culture depicted an interesting finding which was t(1;5)(q23;q33). An extensive search on literature was done for the same genetic change. A similar translocation has been mentioned in literature for other hematologic malignancies but not for same neoplasm; anyhow this translocation was an imbalanced one and led to der(5)t(1;5)(q12-25;q13-q35).http://dx.doi.org/10.1155/2016/8937940 |
| spellingShingle | Ahmad Monabati Akbar Safaei Sadat Nouri Moeinadin Safavi Freidoon Solhjoo A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33) Case Reports in Pathology |
| title | A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33) |
| title_full | A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33) |
| title_fullStr | A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33) |
| title_full_unstemmed | A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33) |
| title_short | A Rare Case of Extramedullary T/Myeloid Mixed Phenotype Acute Leukemia with t(1;5)(q23;q33) |
| title_sort | rare case of extramedullary t myeloid mixed phenotype acute leukemia with t 1 5 q23 q33 |
| url | http://dx.doi.org/10.1155/2016/8937940 |
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