Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial
Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction (AMI), significantly disrupting their recovery. Providing timely and easily accessible psychological interventions using virtual reality-based cognitive–behavioural therapy (VR-CB...
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BMJ Publishing Group
2024-04-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/37/2/e101434.full |
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| author | Jiajun Weng Junbo Ge Jiajia Liu Juying Qian Xiao Huang Yuanyuan Li Juan Peng Yan'e Lu Dong Huang Pingyuan Yang Shikun Xu Lihua Guan Qibing Wang Zexin Zhao Yabin Wei |
| author_facet | Jiajun Weng Junbo Ge Jiajia Liu Juying Qian Xiao Huang Yuanyuan Li Juan Peng Yan'e Lu Dong Huang Pingyuan Yang Shikun Xu Lihua Guan Qibing Wang Zexin Zhao Yabin Wei |
| author_sort | Jiajun Weng |
| collection | DOAJ |
| description | Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction (AMI), significantly disrupting their recovery. Providing timely and easily accessible psychological interventions using virtual reality-based cognitive–behavioural therapy (VR-CBT) could potentially improve both acute and long-term symptoms affecting their mental health.Aims We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit (ICU) during the acute stage of their illness.Methods In this single-blind randomised clinical trial, participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February 2023. Patients who were Han Chinese aged 18–75 years were randomly assigned (1:1) via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support, or the control group to receive standard mental health support only. VR-CBT consisted of four modules and was delivered at the bedside over a 1-week period. Assessments were done at baseline, immediately after treatment and at 3-month follow-up. The intention-to-treat analysis began in June 2023. The primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale (HAM-A).Results Among 148 randomised participants, 70 were assigned to the VR-CBT group and 78 to the control group. The 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention (Cohen’s d=−1.27 (95% confidence interval (CI): −1.64 to −0.90, p<0.001) and 3-month follow-up (Cohen’s d=−0.37 (95% CI: −0.72 to −0.01, p=0.024). Of the 70 participants who received VR-CBT, 62 (88.6%) completed the entire intervention. Cybersickness was the main reported adverse event (n=5).Conclusions Our results indicate that VR-CBT can significantly reduce post-AMI anxiety at the acute stage of the illness; the improvement was maintained at the 3-month follow-up.Trial registration number The trial was registered at www.chictr.org.cn with the identifier: ChiCTR2200066435. |
| format | Article |
| id | doaj-art-59fbc5dd9b30484fa8d14cd0f9732c19 |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
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| series | General Psychiatry |
| spelling | doaj-art-59fbc5dd9b30484fa8d14cd0f9732c192025-01-29T14:40:11ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2024-04-0137210.1136/gpsych-2023-101434Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trialJiajun Weng0Junbo Ge1Jiajia Liu2Juying Qian3Xiao Huang4Yuanyuan Li5Juan Peng6Yan'e Lu7Dong Huang8Pingyuan Yang9Shikun Xu10Lihua Guan11Qibing Wang12Zexin Zhao13Yabin Wei14Psychiatry, Shanghai Mental Health Center, Shanghai, China2 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaPeking University First Hospital, Beijing, China1 Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, Shanghai, China1Nanjing Leads Biolabs Co., Ltd., Nanjing, Jiangsu, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China2 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases; National Clinical Research Center for Interventional Medicine, Shanghai, China4 School of Nursing, Peking University, Beijing, China2 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases; National Clinical Research Center for Interventional Medicine, Shanghai, China1 Department of Psychological Medicine, Zhongshan Hospital Fudan University, Shanghai, China2 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases; National Clinical Research Center for Interventional Medicine, Shanghai, China2 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases; National Clinical Research Center for Interventional Medicine, Shanghai, China2 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases; National Clinical Research Center for Interventional Medicine, Shanghai, China1 Department of Psychological Medicine, Zhongshan Hospital Fudan University, Shanghai, China5 Beijing Key Laboratory of Drug Dependence Research, National Institute on Drug Dependence, Peking University, Beijing, ChinaBackground The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction (AMI), significantly disrupting their recovery. Providing timely and easily accessible psychological interventions using virtual reality-based cognitive–behavioural therapy (VR-CBT) could potentially improve both acute and long-term symptoms affecting their mental health.Aims We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit (ICU) during the acute stage of their illness.Methods In this single-blind randomised clinical trial, participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February 2023. Patients who were Han Chinese aged 18–75 years were randomly assigned (1:1) via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support, or the control group to receive standard mental health support only. VR-CBT consisted of four modules and was delivered at the bedside over a 1-week period. Assessments were done at baseline, immediately after treatment and at 3-month follow-up. The intention-to-treat analysis began in June 2023. The primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale (HAM-A).Results Among 148 randomised participants, 70 were assigned to the VR-CBT group and 78 to the control group. The 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention (Cohen’s d=−1.27 (95% confidence interval (CI): −1.64 to −0.90, p<0.001) and 3-month follow-up (Cohen’s d=−0.37 (95% CI: −0.72 to −0.01, p=0.024). Of the 70 participants who received VR-CBT, 62 (88.6%) completed the entire intervention. Cybersickness was the main reported adverse event (n=5).Conclusions Our results indicate that VR-CBT can significantly reduce post-AMI anxiety at the acute stage of the illness; the improvement was maintained at the 3-month follow-up.Trial registration number The trial was registered at www.chictr.org.cn with the identifier: ChiCTR2200066435.https://gpsych.bmj.com/content/37/2/e101434.full |
| spellingShingle | Jiajun Weng Junbo Ge Jiajia Liu Juying Qian Xiao Huang Yuanyuan Li Juan Peng Yan'e Lu Dong Huang Pingyuan Yang Shikun Xu Lihua Guan Qibing Wang Zexin Zhao Yabin Wei Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial General Psychiatry |
| title | Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial |
| title_full | Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial |
| title_fullStr | Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial |
| title_full_unstemmed | Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial |
| title_short | Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial |
| title_sort | virtual reality based cognitive behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction a randomised clinical trial |
| url | https://gpsych.bmj.com/content/37/2/e101434.full |
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