Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge

Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge

ABSTRACT Degradation of immunoglobulin (Ig) represents an important bacterial immune evasion strategy. For mucosal colonization, degradation of IgA is of particular importance, and many bacteria secrete specific IgA proteases that typically target the extended hinge region of IgA1. Such a specialize...

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Bibliographic Details
Main Authors: Victoria Vassen, Emi Tanaka, Kirsten Moll, Christian Spoerry, Silvia Synowsky, Sally L. Shirran, Ulrich Schwarz-Linek, Edmund Loh, Mattias Svensson, Anna Norrby-Teglund
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
group A Streptococcus
IgA
protease
immune evasion
pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02450-24
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