Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis
Pertussis is a vaccine-preventable infectious disease; however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool the seropositivity rates of IgG antibodies against pertussis toxin (PT-IgG) across the country. We systematically searched PubMed,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2341454 |
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| author | Yao Zhu Wanting Zhang Jie Hu Shuying Luo Yang Zhou Xuewen Tang Rui Yan Xuan Deng Hanqing He |
| author_facet | Yao Zhu Wanting Zhang Jie Hu Shuying Luo Yang Zhou Xuewen Tang Rui Yan Xuan Deng Hanqing He |
| author_sort | Yao Zhu |
| collection | DOAJ |
| description | Pertussis is a vaccine-preventable infectious disease; however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool the seropositivity rates of IgG antibodies against pertussis toxin (PT-IgG) across the country. We systematically searched PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure Database for studies published between January 1, 2010, and June 30, 2023. Studies reporting the seroprevalence of PT-IgG among a healthy Chinese population were included. Pooled estimates were obtained using random-effects meta-analyzes. The meta-analysis included 39 studies (47,778 participants) reporting anti-PT IgG seropositivity rates. The pooled rate for all ages was 7.06% (95% CI, 5.50%-9.07%). Subgroup analyzes showed rates ranging from 6.36% to 12.50% across different age groups. This meta-analysis indicated a low anti-PT IgG seropositivity rate in the Chinese population, particularly among school-aged children and young adults. This finding underscores the urgent need to refine immunization strategies. |
| format | Article |
| id | doaj-art-59f9f78b462d4c099bbf1db16a52396e |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-59f9f78b462d4c099bbf1db16a52396e2025-08-20T02:16:48ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2341454Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysisYao Zhu0Wanting Zhang1Jie Hu2Shuying Luo3Yang Zhou4Xuewen Tang5Rui Yan6Xuan Deng7Hanqing He8Department of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaJiaxing Center for Disease Control and Prevention, Jiaxing, ChinaJiaxing Center for Disease Control and Prevention, Jiaxing, ChinaDepartment of Immunization Program, Yiwu District Center for Disease Control and Prevention, Yiwu, ChinaDepartment of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaDepartment of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaPertussis is a vaccine-preventable infectious disease; however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool the seropositivity rates of IgG antibodies against pertussis toxin (PT-IgG) across the country. We systematically searched PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure Database for studies published between January 1, 2010, and June 30, 2023. Studies reporting the seroprevalence of PT-IgG among a healthy Chinese population were included. Pooled estimates were obtained using random-effects meta-analyzes. The meta-analysis included 39 studies (47,778 participants) reporting anti-PT IgG seropositivity rates. The pooled rate for all ages was 7.06% (95% CI, 5.50%-9.07%). Subgroup analyzes showed rates ranging from 6.36% to 12.50% across different age groups. This meta-analysis indicated a low anti-PT IgG seropositivity rate in the Chinese population, particularly among school-aged children and young adults. This finding underscores the urgent need to refine immunization strategies.https://www.tandfonline.com/doi/10.1080/21645515.2024.2341454Pertussisantibodiespertussis toxinChinameta-analysis |
| spellingShingle | Yao Zhu Wanting Zhang Jie Hu Shuying Luo Yang Zhou Xuewen Tang Rui Yan Xuan Deng Hanqing He Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis Human Vaccines & Immunotherapeutics Pertussis antibodies pertussis toxin China meta-analysis |
| title | Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis |
| title_full | Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis |
| title_fullStr | Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis |
| title_full_unstemmed | Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis |
| title_short | Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis |
| title_sort | seroprevalence of igg antibodies against pertussis toxin in the chinese population a systematic review and meta analysis |
| topic | Pertussis antibodies pertussis toxin China meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2341454 |
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