Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidone
Several materials such as silver are used to enhance graphene oxide (GO) sheets antimicrobial activity. However, these toxic materials decrease its biocompatibility and hinder its usage in many biological applications. Therefore, there is an urgent need to develop nanocomposites that can preserve bo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/iet-nbt.2018.5321 |
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| author | Wafaa A. Khalil Hadeer H.A. Sherif Bahaa A. Hemdan Safaa K.H. Khalil Walid El Hotaby |
| author_facet | Wafaa A. Khalil Hadeer H.A. Sherif Bahaa A. Hemdan Safaa K.H. Khalil Walid El Hotaby |
| author_sort | Wafaa A. Khalil |
| collection | DOAJ |
| description | Several materials such as silver are used to enhance graphene oxide (GO) sheets antimicrobial activity. However, these toxic materials decrease its biocompatibility and hinder its usage in many biological applications. Therefore, there is an urgent need to develop nanocomposites that can preserve both the antimicrobial activity and biocompatibility simultaneously. This work highlights the importance of functionalisation of GO sheets using Polyvinylpyrrolidone (PVP) and decorating them with silver nanoparticles (AgNPs) in order to enhance their antimicrobial activity and biocompatibility at the same time. The structural and morphological characterisations were performed by UV‐Visible, Fourier transform infrared (FTIR), and Raman spectroscopic techniques, X‐ray diffraction (XRD), and high‐resolution transmission electron microscopy (HR‐TEM). The antimicrobial activities of the prepared samples against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans were studied. The cytotoxicity of prepared materials was tested against BJ1 normal skin fibroblasts. The results indicated that the decoration with AgNPs showed a significant increase in the antimicrobial activity of GO and FGO sheets, and functionalisation of GO sheets and GO‐Ag nanocomposite with PVP improved the cell viability about 40 and 35%, respectively. |
| format | Article |
| id | doaj-art-59f6f005a2a24f528c10f46eb7249f66 |
| institution | OA Journals |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-59f6f005a2a24f528c10f46eb7249f662025-08-20T02:05:34ZengWileyIET Nanobiotechnology1751-87411751-875X2019-10-0113881682310.1049/iet-nbt.2018.5321Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidoneWafaa A. Khalil0Hadeer H.A. Sherif1Bahaa A. Hemdan2Safaa K.H. Khalil3Walid El Hotaby4Biophysics DepartmentFaculty of ScienceUniversity of CairoCairoEgyptSpectroscopy DepartmentPhysics DivisionNational Research CentreCairoEgyptEnvironmental Microbiology LabWater Pollution Research DepartmentNational Research CentreCairoEgyptSpectroscopy DepartmentPhysics DivisionNational Research CentreCairoEgyptSpectroscopy DepartmentPhysics DivisionNational Research CentreCairoEgyptSeveral materials such as silver are used to enhance graphene oxide (GO) sheets antimicrobial activity. However, these toxic materials decrease its biocompatibility and hinder its usage in many biological applications. Therefore, there is an urgent need to develop nanocomposites that can preserve both the antimicrobial activity and biocompatibility simultaneously. This work highlights the importance of functionalisation of GO sheets using Polyvinylpyrrolidone (PVP) and decorating them with silver nanoparticles (AgNPs) in order to enhance their antimicrobial activity and biocompatibility at the same time. The structural and morphological characterisations were performed by UV‐Visible, Fourier transform infrared (FTIR), and Raman spectroscopic techniques, X‐ray diffraction (XRD), and high‐resolution transmission electron microscopy (HR‐TEM). The antimicrobial activities of the prepared samples against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans were studied. The cytotoxicity of prepared materials was tested against BJ1 normal skin fibroblasts. The results indicated that the decoration with AgNPs showed a significant increase in the antimicrobial activity of GO and FGO sheets, and functionalisation of GO sheets and GO‐Ag nanocomposite with PVP improved the cell viability about 40 and 35%, respectively.https://doi.org/10.1049/iet-nbt.2018.5321graphene oxide‐silver nanocompositepolyvinylpyrrolidonetoxic materialsbiocompatibilityantimicrobial activitymorphological characterisations |
| spellingShingle | Wafaa A. Khalil Hadeer H.A. Sherif Bahaa A. Hemdan Safaa K.H. Khalil Walid El Hotaby Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidone IET Nanobiotechnology graphene oxide‐silver nanocomposite polyvinylpyrrolidone toxic materials biocompatibility antimicrobial activity morphological characterisations |
| title | Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidone |
| title_full | Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidone |
| title_fullStr | Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidone |
| title_full_unstemmed | Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidone |
| title_short | Biocompatibility enhancement of graphene oxide‐silver nanocomposite by functionalisation with polyvinylpyrrolidone |
| title_sort | biocompatibility enhancement of graphene oxide silver nanocomposite by functionalisation with polyvinylpyrrolidone |
| topic | graphene oxide‐silver nanocomposite polyvinylpyrrolidone toxic materials biocompatibility antimicrobial activity morphological characterisations |
| url | https://doi.org/10.1049/iet-nbt.2018.5321 |
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