Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer
Abstract Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-01031-3 |
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| author | Karl Semaan Rashad Nawfal John Canniff Hunter Savignano Ji-Heui Seo Stephanie E. Siegmund Sarah J. Wu Julia K. Rotow Gwo-Shu Mary Lee Razane El Hajj Chehade Ze Zhang Gunsagar S. Gulati Noa Phillips Garyoung Gary Lee Christopher A. French Michelle S. Hirsch Heather A. Jacene Atish D. Choudhury Toni K. Choueiri Matthew L. Freedman Sylvan C. Baca Jacob E. Berchuck |
| author_facet | Karl Semaan Rashad Nawfal John Canniff Hunter Savignano Ji-Heui Seo Stephanie E. Siegmund Sarah J. Wu Julia K. Rotow Gwo-Shu Mary Lee Razane El Hajj Chehade Ze Zhang Gunsagar S. Gulati Noa Phillips Garyoung Gary Lee Christopher A. French Michelle S. Hirsch Heather A. Jacene Atish D. Choudhury Toni K. Choueiri Matthew L. Freedman Sylvan C. Baca Jacob E. Berchuck |
| author_sort | Karl Semaan |
| collection | DOAJ |
| description | Abstract Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation. We detect dynamic changes in gene regulation from circulating chromatin reflecting the emergence of squamous differentiation, enabling non-invasive diagnosis and monitoring of this resistance phenotype, with potential therapeutic implications. |
| format | Article |
| id | doaj-art-59f3fceb99c84916b5ad6f9cf136e4c9 |
| institution | Kabale University |
| issn | 2397-768X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj-art-59f3fceb99c84916b5ad6f9cf136e4c92025-08-20T04:01:42ZengNature Portfolionpj Precision Oncology2397-768X2025-07-01911710.1038/s41698-025-01031-3Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancerKarl Semaan0Rashad Nawfal1John Canniff2Hunter Savignano3Ji-Heui Seo4Stephanie E. Siegmund5Sarah J. Wu6Julia K. Rotow7Gwo-Shu Mary Lee8Razane El Hajj Chehade9Ze Zhang10Gunsagar S. Gulati11Noa Phillips12Garyoung Gary Lee13Christopher A. French14Michelle S. Hirsch15Heather A. Jacene16Atish D. Choudhury17Toni K. Choueiri18Matthew L. Freedman19Sylvan C. Baca20Jacob E. Berchuck21Department of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Pathology, Brigham and Women’s HospitalDepartment of Pathology, Brigham and Women’s HospitalLowe Center for Thoracic Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Pathology, Brigham and Women’s HospitalDepartment of Pathology, Brigham and Women’s HospitalDepartment of Imaging, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteAbstract Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation. We detect dynamic changes in gene regulation from circulating chromatin reflecting the emergence of squamous differentiation, enabling non-invasive diagnosis and monitoring of this resistance phenotype, with potential therapeutic implications.https://doi.org/10.1038/s41698-025-01031-3 |
| spellingShingle | Karl Semaan Rashad Nawfal John Canniff Hunter Savignano Ji-Heui Seo Stephanie E. Siegmund Sarah J. Wu Julia K. Rotow Gwo-Shu Mary Lee Razane El Hajj Chehade Ze Zhang Gunsagar S. Gulati Noa Phillips Garyoung Gary Lee Christopher A. French Michelle S. Hirsch Heather A. Jacene Atish D. Choudhury Toni K. Choueiri Matthew L. Freedman Sylvan C. Baca Jacob E. Berchuck Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer npj Precision Oncology |
| title | Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer |
| title_full | Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer |
| title_fullStr | Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer |
| title_full_unstemmed | Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer |
| title_short | Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer |
| title_sort | plasma epigenomic profiling reveals treatment emergent squamous transformation in prostate cancer |
| url | https://doi.org/10.1038/s41698-025-01031-3 |
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