Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury
Dysbiosis, i.e., an imbalance in the composition of the intestinal microbiome, has been linked to the etiology of inflammatory bowel diseases (IBD). Secondary bile acids (BAs) are microbiome-derived metabolites increasingly recognized for their important signaling functions in host (patho)physiology...
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| Format: | Article |
| Language: | English |
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Springer Nature
2025-03-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s44321-025-00218-2 |
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| _version_ | 1849725274391838720 |
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| author | Brecht Attema Folkert Kuipers |
| author_facet | Brecht Attema Folkert Kuipers |
| author_sort | Brecht Attema |
| collection | DOAJ |
| description | Dysbiosis, i.e., an imbalance in the composition of the intestinal microbiome, has been linked to the etiology of inflammatory bowel diseases (IBD). Secondary bile acids (BAs) are microbiome-derived metabolites increasingly recognized for their important signaling functions in host (patho)physiology. In this issue of EMBO Molecular Medicine, Jalil et al (Jalil et al, 2025) report that increased production of secondary BAs upon administration of the human bacterium Clostridium scindens (C. scindens) improves colonic health in mice with chemically-induced colitis via activation of the membrane bound BA receptor TGR5. These findings indicate an important role for secondary BA signaling in colon mucosal healing upon injury and suggest that modulation of microbiome composition could serve as a therapeutic approach for patients with IBD. |
| format | Article |
| id | doaj-art-59f33866e12b4f258652b391dfd3eddc |
| institution | DOAJ |
| issn | 1757-4684 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-59f33866e12b4f258652b391dfd3eddc2025-08-20T03:10:31ZengSpringer NatureEMBO Molecular Medicine1757-46842025-03-0117586386510.1038/s44321-025-00218-2Microbiome-derived secondary bile acids promote repair of colonic mucosa after injuryBrecht Attema0Folkert Kuipers1European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center GroningenEuropean Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center GroningenDysbiosis, i.e., an imbalance in the composition of the intestinal microbiome, has been linked to the etiology of inflammatory bowel diseases (IBD). Secondary bile acids (BAs) are microbiome-derived metabolites increasingly recognized for their important signaling functions in host (patho)physiology. In this issue of EMBO Molecular Medicine, Jalil et al (Jalil et al, 2025) report that increased production of secondary BAs upon administration of the human bacterium Clostridium scindens (C. scindens) improves colonic health in mice with chemically-induced colitis via activation of the membrane bound BA receptor TGR5. These findings indicate an important role for secondary BA signaling in colon mucosal healing upon injury and suggest that modulation of microbiome composition could serve as a therapeutic approach for patients with IBD.https://doi.org/10.1038/s44321-025-00218-2 |
| spellingShingle | Brecht Attema Folkert Kuipers Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury EMBO Molecular Medicine |
| title | Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury |
| title_full | Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury |
| title_fullStr | Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury |
| title_full_unstemmed | Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury |
| title_short | Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury |
| title_sort | microbiome derived secondary bile acids promote repair of colonic mucosa after injury |
| url | https://doi.org/10.1038/s44321-025-00218-2 |
| work_keys_str_mv | AT brechtattema microbiomederivedsecondarybileacidspromoterepairofcolonicmucosaafterinjury AT folkertkuipers microbiomederivedsecondarybileacidspromoterepairofcolonicmucosaafterinjury |