Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant Patient
Introduction. Hematopoietic stem cell transplant is an established management in various blood disorders. This contemporary management has improved patient survival; tackling immunosuppression and managing post-transplant complications is of prime importance. Post-transplant Diabetes Mellitus is one...
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Romanian Society of Hematology
2025-06-01
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| Series: | Documenta Haematologica |
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| Online Access: | https://www.dhrrh.ro/wp-content/uploads/2025/06/DHRRH-2025-2-art7.pdf |
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| author | Omkar KALIDASRAO CHOUDHARI Disha SATYA Naveen GUPTA Priyanka SONI Purvish PARIKH Hemant MALHOTRA |
| author_facet | Omkar KALIDASRAO CHOUDHARI Disha SATYA Naveen GUPTA Priyanka SONI Purvish PARIKH Hemant MALHOTRA |
| author_sort | Omkar KALIDASRAO CHOUDHARI |
| collection | DOAJ |
| description | Introduction. Hematopoietic stem cell transplant is an established management in various blood disorders. This contemporary management has improved patient survival; tackling immunosuppression and managing post-transplant complications is of prime importance. Post-transplant Diabetes Mellitus is one of the complications encountered in these patients, and various causes include Calcineurin inhibitors (CNIs), Cytomegalovirus (CMV) viremia, Graft versus host disease (GVHD), and Insulin resistance.
Case Presentation. A 20-year-old male known case of severe aplastic anaemia with matched sibling donor (MSD) allogeneic stem cell transplant day + 351 presented in drowsy condition in casualty. His blood sugar level was 584mg/dl, and arterial blood gas (ABG) showed metabolic acidosis. Urine ketones were moderately positive. The patient was diagnosed with Diabetic Ketoacidosis, was managed in the Intensive Care Unit (ICU), gradually recovered with insulin therapy and was discharged.
Conclusion. Regular close follow-up is required to detect post-transplant DM(PTDM) for better prognosis. |
| format | Article |
| id | doaj-art-59f1f7ff0d7f40d2aebf995723251f49 |
| institution | DOAJ |
| issn | 3008-220X 2972-242X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Romanian Society of Hematology |
| record_format | Article |
| series | Documenta Haematologica |
| spelling | doaj-art-59f1f7ff0d7f40d2aebf995723251f492025-08-20T03:23:51ZengRomanian Society of HematologyDocumenta Haematologica3008-220X2972-242X2025-06-013210711010.59854/dhrrh.2025.3.2.107Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant PatientOmkar KALIDASRAO CHOUDHARI0Disha SATYA1Naveen GUPTA2https://orcid.org/0000-0002-2695-1985Priyanka SONI3Purvish PARIKH4https://orcid.org/0000-0003-3813-8788Hemant MALHOTRA5DM Resident, Department of Clinical Hematology, Mahatma Gandhi Medical College and Hospital, Jaipur, IndiaDM Resident, Department of Clinical Hematology, Mahatma Gandhi Medical College and Hospital, Jaipur, IndiaAssociate Professor, Department of Clinical Hematology, Mahatma Gandhi Medical College and Hospital, Jaipur, IndiaAssistant Professor, Department of Clinical Hematology, Mahatma Gandhi Medical College and Hospital, Jaipur, IndiaProfessor and Head of Department, Department of Clinical Hematology, Mahatma Gandhi Medical College and Hospital, Jaipur, IndiaProfessor and Head of Department, Department of Medical Oncology, Mahatma Gandhi Medical College and Hospital, Jaipur, IndiaIntroduction. Hematopoietic stem cell transplant is an established management in various blood disorders. This contemporary management has improved patient survival; tackling immunosuppression and managing post-transplant complications is of prime importance. Post-transplant Diabetes Mellitus is one of the complications encountered in these patients, and various causes include Calcineurin inhibitors (CNIs), Cytomegalovirus (CMV) viremia, Graft versus host disease (GVHD), and Insulin resistance. Case Presentation. A 20-year-old male known case of severe aplastic anaemia with matched sibling donor (MSD) allogeneic stem cell transplant day + 351 presented in drowsy condition in casualty. His blood sugar level was 584mg/dl, and arterial blood gas (ABG) showed metabolic acidosis. Urine ketones were moderately positive. The patient was diagnosed with Diabetic Ketoacidosis, was managed in the Intensive Care Unit (ICU), gradually recovered with insulin therapy and was discharged. Conclusion. Regular close follow-up is required to detect post-transplant DM(PTDM) for better prognosis.https://www.dhrrh.ro/wp-content/uploads/2025/06/DHRRH-2025-2-art7.pdfpost-transplant dm(ptdm)calcineurin inhibitorshematopoietic stem cell transplant (hsct) |
| spellingShingle | Omkar KALIDASRAO CHOUDHARI Disha SATYA Naveen GUPTA Priyanka SONI Purvish PARIKH Hemant MALHOTRA Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant Patient Documenta Haematologica post-transplant dm(ptdm) calcineurin inhibitors hematopoietic stem cell transplant (hsct) |
| title | Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant Patient |
| title_full | Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant Patient |
| title_fullStr | Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant Patient |
| title_full_unstemmed | Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant Patient |
| title_short | Tacrolimus-Induced Diabetic Ketoacidosis (DKA) in Post Bone Marrow Transplant Patient |
| title_sort | tacrolimus induced diabetic ketoacidosis dka in post bone marrow transplant patient |
| topic | post-transplant dm(ptdm) calcineurin inhibitors hematopoietic stem cell transplant (hsct) |
| url | https://www.dhrrh.ro/wp-content/uploads/2025/06/DHRRH-2025-2-art7.pdf |
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