T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities
Cervical cancer is the third most common malignancy among Chinese women in both incidence and mortality. Its progression is closely linked to complex interactions among immune cells within the tumor microenvironment (TME). As key components of the immune landscape, different T cell subsets play dive...
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| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612032/full |
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| author | Weilin Guo Weilin Guo Lan Dai Lan Dai Lihua Qiu Lihua Qiu |
| author_facet | Weilin Guo Weilin Guo Lan Dai Lan Dai Lihua Qiu Lihua Qiu |
| author_sort | Weilin Guo |
| collection | DOAJ |
| description | Cervical cancer is the third most common malignancy among Chinese women in both incidence and mortality. Its progression is closely linked to complex interactions among immune cells within the tumor microenvironment (TME). As key components of the immune landscape, different T cell subsets play diverse and dynamic roles in shaping tumor immunity. This review provides a comprehensive overview of the roles of various T cell subsets in the TME of cervical cancer, with a focus on their distribution, functional heterogeneity, dynamic balance, and variations across different pathological subtypes and disease stages. We also highlight the intricate crosstalk between T cells and other immune cells in the TME and discuss recent advances in T cell-related immunotherapies for cervical cancer, including immune checkpoint inhibitors and HPV-targeted vaccines. By elucidating the roles of distinct T cell subsets and relevant immunotherapeutic approaches within the TME, this review provides insights into potential therapeutic targets and approaches for improving cervical cancer treatment and patient outcome. |
| format | Article |
| id | doaj-art-59ece71cc3f84d4b8996cb1d37f8aa5b |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-59ece71cc3f84d4b8996cb1d37f8aa5b2025-08-20T02:32:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16120321612032T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunitiesWeilin Guo0Weilin Guo1Lan Dai2Lan Dai3Lihua Qiu4Lihua Qiu5Department of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCervical cancer is the third most common malignancy among Chinese women in both incidence and mortality. Its progression is closely linked to complex interactions among immune cells within the tumor microenvironment (TME). As key components of the immune landscape, different T cell subsets play diverse and dynamic roles in shaping tumor immunity. This review provides a comprehensive overview of the roles of various T cell subsets in the TME of cervical cancer, with a focus on their distribution, functional heterogeneity, dynamic balance, and variations across different pathological subtypes and disease stages. We also highlight the intricate crosstalk between T cells and other immune cells in the TME and discuss recent advances in T cell-related immunotherapies for cervical cancer, including immune checkpoint inhibitors and HPV-targeted vaccines. By elucidating the roles of distinct T cell subsets and relevant immunotherapeutic approaches within the TME, this review provides insights into potential therapeutic targets and approaches for improving cervical cancer treatment and patient outcome.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612032/fullT celltumor microenvironment (TME)cervical cancerimmune regulationimmunotherapy |
| spellingShingle | Weilin Guo Weilin Guo Lan Dai Lan Dai Lihua Qiu Lihua Qiu T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities Frontiers in Immunology T cell tumor microenvironment (TME) cervical cancer immune regulation immunotherapy |
| title | T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities |
| title_full | T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities |
| title_fullStr | T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities |
| title_full_unstemmed | T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities |
| title_short | T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities |
| title_sort | t cell subsets in cervical cancer tumor microenvironment advances and therapeutic opportunities |
| topic | T cell tumor microenvironment (TME) cervical cancer immune regulation immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612032/full |
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