Integrated 3D imaging of FFPE lung tissue combining microCT, light and electron microscopy allows for contextualized ultrastructural and histological analysis

Integrated 3D imaging of FFPE lung tissue combining microCT, light and electron microscopy allows for contextualized ultrastructural and histological analysis

Abstract Classical histopathology of formalin fixed and paraffin embedded (FFPE) tissue using light microscopy (LM) remains the undisputed gold standard in biomedical microstructural lung tissue analysis. To extend this method, we developed an integrative imaging and processing pipeline which adds 3...

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Bibliographic Details
Main Authors: Johanna Reiser, Jonas Albers, Angelika Svetlove, Mara Mertiny, Felix K. F. Kommoss, Constantin Schwab, Anna Schneemann, Giuliana Tromba, Irene Wacker, Ronald E. Curticean, Rasmus R. Schroeder, Hans-Ulrich Kauczor, Mark O. Wielpütz, Christian Dullin, Willi L. Wagner
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Propagation based imaging
Phase contrast
Virtual histology
FFPE
Image registration
Online Access:https://doi.org/10.1038/s41598-025-02770-w
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