Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018)
Relevance. Annual elevation of enterovirus infection (EVI) incidence in the Russian Federation as well as in the Sakhalin region determine a necessity of continuous surveillance involving molecular-genetic methods and phylogenetic analysis. Objective: to highlight epidemiological and mol...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Numikom LLC
2019-11-01
|
| Series: | Эпидемиология и вакцинопрофилактика |
| Subjects: | |
| Online Access: | https://www.epidemvac.ru/jour/article/view/833 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691469509558272 |
|---|---|
| author | E. Yu. Sapega L. V. Butakova O. E. Trotsenko O. A. Funtusova G. P. Kovtoniuk |
| author_facet | E. Yu. Sapega L. V. Butakova O. E. Trotsenko O. A. Funtusova G. P. Kovtoniuk |
| author_sort | E. Yu. Sapega |
| collection | DOAJ |
| description | Relevance. Annual elevation of enterovirus infection (EVI) incidence in the Russian Federation as well as in the Sakhalin region determine a necessity of continuous surveillance involving molecular-genetic methods and phylogenetic analysis. Objective: to highlight epidemiological and molecular-genetic peculiarities of EVI in the Sakhalin region during 2016-2018 years. Materials and methods. Analysis of enterovirus incidence were based on official statistical reporting forms. The structure of enterovirus types was evaluated by means of molecular methods and followed by phylogenetic analysis. Results and discussion. A deterioration of epidemic situation concerning EVI that began in 2016 in the Sakhalin region included elevation of incidence and registration of enterovirus outbreaks in childcare facilities triggered by introduction of new enterovirus types or those that were not circulating for a long time suchas Coxsackievirus A-6, Coxsackievirus A-10, Coxsackievirus A-16, ECHO-9. The phylogenetic analysis of Coxsackievirus A-16 detected in the Sakhalin region revealed their similarities with two genovariants of B genogroup (В1а и В1b) that were continuously circulating in Russia and China. In addition, enterovirus ECHO-9 that was also circulating in other constituent entities of the Russian Federation was isolated in Sakhalin region from patients suffering from viral meningitis including two children from two different infection cites of EVI group incidence. Conclusion. An unfavorable epidemic situation concerning EVI was revealed in the Sakhalin region during the last three years of surveillance. It was caused by introduction and further spread among population of Coxsackieviruses A-6, 10, 16 and ECHO-9 that presumably have Russian or foreign origin. |
| format | Article |
| id | doaj-art-59dc21d5fae84d6d866a6ee7f5ec779b |
| institution | DOAJ |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2019-11-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-59dc21d5fae84d6d866a6ee7f5ec779b2025-08-20T03:21:01ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942019-11-01185334110.31631/2073-3046-2019-18-5-33-41581Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018)E. Yu. Sapega0L. V. Butakova1O. E. Trotsenko2O. A. Funtusova3G. P. Kovtoniuk4Khabarovsk research institute of epidemiology and microbiologyKhabarovsk research institute of epidemiology and microbiologyKhabarovsk research institute of epidemiology and microbiologyRegional Rospotrebnadzor office in the Sakhalin regionRegional Rospotrebnadzor office in the Sakhalin regionRelevance. Annual elevation of enterovirus infection (EVI) incidence in the Russian Federation as well as in the Sakhalin region determine a necessity of continuous surveillance involving molecular-genetic methods and phylogenetic analysis. Objective: to highlight epidemiological and molecular-genetic peculiarities of EVI in the Sakhalin region during 2016-2018 years. Materials and methods. Analysis of enterovirus incidence were based on official statistical reporting forms. The structure of enterovirus types was evaluated by means of molecular methods and followed by phylogenetic analysis. Results and discussion. A deterioration of epidemic situation concerning EVI that began in 2016 in the Sakhalin region included elevation of incidence and registration of enterovirus outbreaks in childcare facilities triggered by introduction of new enterovirus types or those that were not circulating for a long time suchas Coxsackievirus A-6, Coxsackievirus A-10, Coxsackievirus A-16, ECHO-9. The phylogenetic analysis of Coxsackievirus A-16 detected in the Sakhalin region revealed their similarities with two genovariants of B genogroup (В1а и В1b) that were continuously circulating in Russia and China. In addition, enterovirus ECHO-9 that was also circulating in other constituent entities of the Russian Federation was isolated in Sakhalin region from patients suffering from viral meningitis including two children from two different infection cites of EVI group incidence. Conclusion. An unfavorable epidemic situation concerning EVI was revealed in the Sakhalin region during the last three years of surveillance. It was caused by introduction and further spread among population of Coxsackieviruses A-6, 10, 16 and ECHO-9 that presumably have Russian or foreign origin.https://www.epidemvac.ru/jour/article/view/833enterovirus infectionenterovirusepidemiological analysisoutbreakmolecular genetic studiessakhalin region |
| spellingShingle | E. Yu. Sapega L. V. Butakova O. E. Trotsenko O. A. Funtusova G. P. Kovtoniuk Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018) Эпидемиология и вакцинопрофилактика enterovirus infection enterovirus epidemiological analysis outbreak molecular genetic studies sakhalin region |
| title | Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018) |
| title_full | Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018) |
| title_fullStr | Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018) |
| title_full_unstemmed | Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018) |
| title_short | Aspects of Enterovirus Infection Molecular Epidemiology in Sakhalin Region (during years 2016–2018) |
| title_sort | aspects of enterovirus infection molecular epidemiology in sakhalin region during years 2016 2018 |
| topic | enterovirus infection enterovirus epidemiological analysis outbreak molecular genetic studies sakhalin region |
| url | https://www.epidemvac.ru/jour/article/view/833 |
| work_keys_str_mv | AT eyusapega aspectsofenterovirusinfectionmolecularepidemiologyinsakhalinregionduringyears20162018 AT lvbutakova aspectsofenterovirusinfectionmolecularepidemiologyinsakhalinregionduringyears20162018 AT oetrotsenko aspectsofenterovirusinfectionmolecularepidemiologyinsakhalinregionduringyears20162018 AT oafuntusova aspectsofenterovirusinfectionmolecularepidemiologyinsakhalinregionduringyears20162018 AT gpkovtoniuk aspectsofenterovirusinfectionmolecularepidemiologyinsakhalinregionduringyears20162018 |