Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice
Summary: Home information profoundly influences behavioral states in both humans and animals. However, how “home” is represented in the brain and its role in driving diverse related behaviors remain elusive. Here, we demonstrate that home bedding contains sufficient home information to modulate affe...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
|
| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724011938 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850185179609432064 |
|---|---|
| author | Xiaoya Su Bo Lei Junyue He Yunlong Liu Ao Wang Yikai Tang Weixuan Liu Yi Zhong |
| author_facet | Xiaoya Su Bo Lei Junyue He Yunlong Liu Ao Wang Yikai Tang Weixuan Liu Yi Zhong |
| author_sort | Xiaoya Su |
| collection | DOAJ |
| description | Summary: Home information profoundly influences behavioral states in both humans and animals. However, how “home” is represented in the brain and its role in driving diverse related behaviors remain elusive. Here, we demonstrate that home bedding contains sufficient home information to modulate affective behaviors, including aversion responses, defensive aggression, and mating behaviors. These varied responses to home information are mediated by gama-aminobutyric acid (GABA)ergic neurons in the lateral hypothalamus (LHGABA). Inhibiting LHGABA abolishes, while activating mimics, the effects of home bedding on these behaviors across different contexts. Specifically, projections from LHGABA to the ventral tegmental area (VTA) mediate the relaxation of aversive emotion, while projections to the periaqueductal gray (PAG) initiate defensive concerns. Thus, our data suggest that home information in different contexts converges to activate distinct subgroups of the LHGABA, which, in turn, elicit appropriate affective behaviors in relieving aversion, fighting intruders, or enhancing mating through involving distinct downstream projections. |
| format | Article |
| id | doaj-art-59dbb8bca32544b79884c82bc3dc3868 |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-59dbb8bca32544b79884c82bc3dc38682025-08-20T02:16:49ZengElsevierCell Reports2211-12472024-11-01431111484210.1016/j.celrep.2024.114842Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in miceXiaoya Su0Bo Lei1Junyue He2Yunlong Liu3Ao Wang4Yikai Tang5Weixuan Liu6Yi Zhong7School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; McGovern Institute of Brain Research, Beijing 100084, P.R. ChinaSchool of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; McGovern Institute of Brain Research, Beijing 100084, P.R. China; Beijing Academy of Artificial Intelligence, Beijing 100084, P.R. China; Corresponding authorSchool of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; McGovern Institute of Brain Research, Beijing 100084, P.R. China; Peking University, Tsinghua University, National Institute Biological Science Joint Graduate Program, Beijing, P.R. ChinaNeuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, CanadaSchool of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; McGovern Institute of Brain Research, Beijing 100084, P.R. China; School of Life Sciences, Peking University, Beijing 100871, P.R. ChinaSchool of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; McGovern Institute of Brain Research, Beijing 100084, P.R. ChinaSchool of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; McGovern Institute of Brain Research, Beijing 100084, P.R. ChinaSchool of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; McGovern Institute of Brain Research, Beijing 100084, P.R. China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, P.R. China; MOE Key Laboratory of Protein Sciences, Tsinghua University, Beijing 100084, P.R. China; Corresponding authorSummary: Home information profoundly influences behavioral states in both humans and animals. However, how “home” is represented in the brain and its role in driving diverse related behaviors remain elusive. Here, we demonstrate that home bedding contains sufficient home information to modulate affective behaviors, including aversion responses, defensive aggression, and mating behaviors. These varied responses to home information are mediated by gama-aminobutyric acid (GABA)ergic neurons in the lateral hypothalamus (LHGABA). Inhibiting LHGABA abolishes, while activating mimics, the effects of home bedding on these behaviors across different contexts. Specifically, projections from LHGABA to the ventral tegmental area (VTA) mediate the relaxation of aversive emotion, while projections to the periaqueductal gray (PAG) initiate defensive concerns. Thus, our data suggest that home information in different contexts converges to activate distinct subgroups of the LHGABA, which, in turn, elicit appropriate affective behaviors in relieving aversion, fighting intruders, or enhancing mating through involving distinct downstream projections.http://www.sciencedirect.com/science/article/pii/S2211124724011938CP: NeuroscienceCP: Cell biology |
| spellingShingle | Xiaoya Su Bo Lei Junyue He Yunlong Liu Ao Wang Yikai Tang Weixuan Liu Yi Zhong Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice Cell Reports CP: Neuroscience CP: Cell biology |
| title | Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice |
| title_full | Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice |
| title_fullStr | Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice |
| title_full_unstemmed | Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice |
| title_short | Identification of GABAergic subpopulations in the lateral hypothalamus for home-driven behaviors in mice |
| title_sort | identification of gabaergic subpopulations in the lateral hypothalamus for home driven behaviors in mice |
| topic | CP: Neuroscience CP: Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724011938 |
| work_keys_str_mv | AT xiaoyasu identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice AT bolei identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice AT junyuehe identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice AT yunlongliu identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice AT aowang identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice AT yikaitang identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice AT weixuanliu identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice AT yizhong identificationofgabaergicsubpopulationsinthelateralhypothalamusforhomedrivenbehaviorsinmice |