Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface.

Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface.

The cross-talk at the prefronto-striatal interface involves excitatory amino acids, different receptors, transducers and modulators. We investigated long-term effects of a prepuberal, subchronic 5-HT7-R agonist (LP-211) on adult behaviour, amino acids and synaptic markers in a model for Attention-De...

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Main Authors: Lucia A Ruocco, Concetta Treno, Ugo A Gironi Carnevale, Claudio Arra, Gianpiero Boatto, Maria Nieddu, Cristina Pagano, Placido Illiano, Fabiana Barbato, Angela Tino, Ezio Carboni, Giovanni Laviola, Enza Lacivita, Marcello Leopoldo, Walter Adriani, Adolfo G Sadile
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0083003&type=printable
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