Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease

Abstract Rigidity, a cardinal symptom of Parkinson’s disease (PD), remains challenging to assess objectively. A torque-angle instrument was developed to quantify muscle tone, providing two parameters: bias difference and elastic coefficient. This study aimed to investigate the association of the ins...

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Bibliographic Details
Main Authors:	Yoshikazu Nakano, Shigeki Hirano, Mitsuyoshi Tamura, Yume Koizumi, Yoshihisa Kitayama, Michiko Izumi, Masahide Suzuki, Kosuke Yamagishi, Yutaro Suzuki, Shinobu Ikeda, Ayaka Arase, Tatsuya Yamamoto, Yoshitaka Yamanaka, Atsuhiko Sugiyama, Kazumoto Shibuya, Takuro Horikoshi, Takashi Uno, David Eidelberg, Satoshi Kuwabara
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Series:	Scientific Reports
Subjects:	Parkinson’s disease Rigidity Torque-angle measurement Brain perfusion Single photon emission tomography (SPECT) Network analysis
Online Access:	https://doi.org/10.1038/s41598-025-91567-y
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Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease

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