Effect of acute renal injury on short-term prognosis after heart transplantation
ObjectiveAcute kidney injury （AKI） is a common complication of heart transplantation （HT）. The effect of AKI on the prognosis of HT patients remains elusive. The purpose of this study was to examine the effect of AKI on short-term （90 days） prognosis of HT.MethodsFrom January 2010 to October 2020， a...
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Editorial Department of Journal of Clinical Nephrology
2022-12-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.002 |
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| author | Fu Lei Wu Yan-hua Song Li Hu Peng-hua Chen Yuan-han Dong Wei Wu Yi-jin Wu Min Liang Xin-ling |
| author_facet | Fu Lei Wu Yan-hua Song Li Hu Peng-hua Chen Yuan-han Dong Wei Wu Yi-jin Wu Min Liang Xin-ling |
| author_sort | Fu Lei |
| collection | DOAJ |
| description | ObjectiveAcute kidney injury （AKI） is a common complication of heart transplantation （HT）. The effect of AKI on the prognosis of HT patients remains elusive. The purpose of this study was to examine the effect of AKI on short-term （90 days） prognosis of HT.MethodsFrom January 2010 to October 2020， a total of 137 HT recipients were retrospectively reviewed at Guangdong Provincial People's Hospital. According to the KDIGO criteria for AKI diagnosis and classification， they were assigned into three groups of non-AKI （<italic>n</italic>=16）， mild AKI （grade 1/2， <italic>n</italic>=67） and severe AKI （grade 3， <italic>n</italic>=54）. Primary endpoint was all-cause mortality at 90 days post-operation. Finally Kaplan-Meier survival and Cox regression analyses were performed for evaluating the risk factors of AKI on short-term prognosis （90 days） after HT.ResultsThe mortality rate within 90 days post-HT was around 22.6% （<italic>n</italic>=31）. Kaplan-Meier survival analysis indicated that 90-day mortality of patients with severe AKI was significantly higher than that of other groups （<italic>P</italic><0.001）. Multivariate Cox regression revealed an elevated risk of all-cause mortality at 90 days post-HT in severe AKI group （<italic>HR</italic>=8.783， 95% <italic>CI</italic>： 11.142-67.557， <italic>P</italic>=0.037）.ConclusionPatients with severe AKI have an elevated risk of morality at 90 days post-HT. Therefore early identification and timely intervention of severe AKI may improve patient prognosis. |
| format | Article |
| id | doaj-art-59d94f4f6d9e40589e33a86efc437cc8 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-12-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-59d94f4f6d9e40589e33a86efc437cc82025-08-20T02:28:47ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-12-012297397833236831Effect of acute renal injury on short-term prognosis after heart transplantationFu LeiWu Yan-huaSong LiHu Peng-huaChen Yuan-hanDong WeiWu Yi-jinWu MinLiang Xin-lingObjectiveAcute kidney injury （AKI） is a common complication of heart transplantation （HT）. The effect of AKI on the prognosis of HT patients remains elusive. The purpose of this study was to examine the effect of AKI on short-term （90 days） prognosis of HT.MethodsFrom January 2010 to October 2020， a total of 137 HT recipients were retrospectively reviewed at Guangdong Provincial People's Hospital. According to the KDIGO criteria for AKI diagnosis and classification， they were assigned into three groups of non-AKI （<italic>n</italic>=16）， mild AKI （grade 1/2， <italic>n</italic>=67） and severe AKI （grade 3， <italic>n</italic>=54）. Primary endpoint was all-cause mortality at 90 days post-operation. Finally Kaplan-Meier survival and Cox regression analyses were performed for evaluating the risk factors of AKI on short-term prognosis （90 days） after HT.ResultsThe mortality rate within 90 days post-HT was around 22.6% （<italic>n</italic>=31）. Kaplan-Meier survival analysis indicated that 90-day mortality of patients with severe AKI was significantly higher than that of other groups （<italic>P</italic><0.001）. Multivariate Cox regression revealed an elevated risk of all-cause mortality at 90 days post-HT in severe AKI group （<italic>HR</italic>=8.783， 95% <italic>CI</italic>： 11.142-67.557， <italic>P</italic>=0.037）.ConclusionPatients with severe AKI have an elevated risk of morality at 90 days post-HT. Therefore early identification and timely intervention of severe AKI may improve patient prognosis.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.002Acute kidney injuryHeart transplantationShort-term prognosis |
| spellingShingle | Fu Lei Wu Yan-hua Song Li Hu Peng-hua Chen Yuan-han Dong Wei Wu Yi-jin Wu Min Liang Xin-ling Effect of acute renal injury on short-term prognosis after heart transplantation Linchuang shenzangbing zazhi Acute kidney injury Heart transplantation Short-term prognosis |
| title | Effect of acute renal injury on short-term prognosis after heart transplantation |
| title_full | Effect of acute renal injury on short-term prognosis after heart transplantation |
| title_fullStr | Effect of acute renal injury on short-term prognosis after heart transplantation |
| title_full_unstemmed | Effect of acute renal injury on short-term prognosis after heart transplantation |
| title_short | Effect of acute renal injury on short-term prognosis after heart transplantation |
| title_sort | effect of acute renal injury on short term prognosis after heart transplantation |
| topic | Acute kidney injury Heart transplantation Short-term prognosis |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.12.002 |
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