Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease
Cardiovascular disease is the most common cause of mortality globally, accounting for approximately one out of three deaths. The main underlying pathology is atherosclerosis, a dyslipidemia-driven, chronic inflammatory disease. The interplay between immune cells and non-immune cells is of great impo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/12/1557 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850239755227234304 |
|---|---|
| author | Yuting Wu Irem Avcilar-Kücükgöze Donato Santovito Dorothee Atzler |
| author_facet | Yuting Wu Irem Avcilar-Kücükgöze Donato Santovito Dorothee Atzler |
| author_sort | Yuting Wu |
| collection | DOAJ |
| description | Cardiovascular disease is the most common cause of mortality globally, accounting for approximately one out of three deaths. The main underlying pathology is atherosclerosis, a dyslipidemia-driven, chronic inflammatory disease. The interplay between immune cells and non-immune cells is of great importance in the complex process of atherogenesis. During atheroprogression, intracellular metabolic pathways, such as amino acid metabolism, are master switches of immune cell function. Autophagy, an important stress survival mechanism involved in maintaining (immune) cell homeostasis, is crucial during the development of atherosclerosis and is strongly regulated by the availability of amino acids. In this review, we focus on the interplay between amino acids, especially L-leucine, L-arginine, and L-glutamine, and autophagy during atherosclerosis development and progression, highlighting potential therapeutic perspectives. |
| format | Article |
| id | doaj-art-59d7f6d06f8448c9b8457fba5f668d61 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-59d7f6d06f8448c9b8457fba5f668d612025-08-20T02:01:04ZengMDPI AGBiomolecules2218-273X2024-12-011412155710.3390/biom14121557Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular DiseaseYuting Wu0Irem Avcilar-Kücükgöze1Donato Santovito2Dorothee Atzler3Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, 80336 Munich, GermanyInstitute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, 80336 Munich, GermanyInstitute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, 80336 Munich, GermanyInstitute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, 80336 Munich, GermanyCardiovascular disease is the most common cause of mortality globally, accounting for approximately one out of three deaths. The main underlying pathology is atherosclerosis, a dyslipidemia-driven, chronic inflammatory disease. The interplay between immune cells and non-immune cells is of great importance in the complex process of atherogenesis. During atheroprogression, intracellular metabolic pathways, such as amino acid metabolism, are master switches of immune cell function. Autophagy, an important stress survival mechanism involved in maintaining (immune) cell homeostasis, is crucial during the development of atherosclerosis and is strongly regulated by the availability of amino acids. In this review, we focus on the interplay between amino acids, especially L-leucine, L-arginine, and L-glutamine, and autophagy during atherosclerosis development and progression, highlighting potential therapeutic perspectives.https://www.mdpi.com/2218-273X/14/12/1557atherosclerosisamino acidsautophagycardiovascular disease |
| spellingShingle | Yuting Wu Irem Avcilar-Kücükgöze Donato Santovito Dorothee Atzler Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease Biomolecules atherosclerosis amino acids autophagy cardiovascular disease |
| title | Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease |
| title_full | Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease |
| title_fullStr | Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease |
| title_full_unstemmed | Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease |
| title_short | Amino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease |
| title_sort | amino acid metabolism and autophagy in atherosclerotic cardiovascular disease |
| topic | atherosclerosis amino acids autophagy cardiovascular disease |
| url | https://www.mdpi.com/2218-273X/14/12/1557 |
| work_keys_str_mv | AT yutingwu aminoacidmetabolismandautophagyinatheroscleroticcardiovasculardisease AT iremavcilarkucukgoze aminoacidmetabolismandautophagyinatheroscleroticcardiovasculardisease AT donatosantovito aminoacidmetabolismandautophagyinatheroscleroticcardiovasculardisease AT dorotheeatzler aminoacidmetabolismandautophagyinatheroscleroticcardiovasculardisease |