Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb
Neurokinin A and B are putative inflammatory mediators. We assessed their ability to alter prenodal lymphatic resistance. Intralymphatic neurokinin A (3.0 × 10−6, 3.0 × 10−5 and 3.0 × 10−4 mol l−1) significantly constricted lymphatics at the two highest doses. Preliminary experiments suggested that...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519200036X |
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| _version_ | 1841524541625466880 |
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| author | David E. Dobbins |
| author_facet | David E. Dobbins |
| author_sort | David E. Dobbins |
| collection | DOAJ |
| description | Neurokinin A and B are putative inflammatory mediators. We assessed their ability to alter prenodal lymphatic resistance. Intralymphatic neurokinin A (3.0 × 10−6, 3.0 × 10−5 and 3.0 × 10−4 mol l−1) significantly constricted lymphatics at the two highest doses. Preliminary experiments suggested that neurokinin B might dilate lymphatics. To test this, lymphatic pressure was increased by norepinephrine (3.1 × 10−6 mol l−1). Neurokinin B (2.7 × 10−4 mol l−1) was then infused intralymphatically during norepinephrine infusion. Norepinephrine increased perfusion pressure from 5.6 ± 0.6 mmHg to 12.1 ± 1.4 mmHg. Subsequent infusion of neurokinin B significantly decreased lymphatic perfusion pressure from 11.9 ± 1.3 mmHg to 9.9 ± 1.1 mmHg. These data indicate that neurokinin A and B can alter lymphatic resistance and are consistent with the hypothesis that lymph vessel function may be subject to modulation by neurokinins. |
| format | Article |
| id | doaj-art-59d7c2092c574e1bb181edfaab84f45b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-59d7c2092c574e1bb181edfaab84f45b2025-02-03T05:52:53ZengWileyMediators of Inflammation0962-93511466-18611992-01-011424124610.1155/S096293519200036XNeuropeptide modulation of lymphatic smooth muscle tone in the canine forelimbDavid E. Dobbins0Department of Physiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USANeurokinin A and B are putative inflammatory mediators. We assessed their ability to alter prenodal lymphatic resistance. Intralymphatic neurokinin A (3.0 × 10−6, 3.0 × 10−5 and 3.0 × 10−4 mol l−1) significantly constricted lymphatics at the two highest doses. Preliminary experiments suggested that neurokinin B might dilate lymphatics. To test this, lymphatic pressure was increased by norepinephrine (3.1 × 10−6 mol l−1). Neurokinin B (2.7 × 10−4 mol l−1) was then infused intralymphatically during norepinephrine infusion. Norepinephrine increased perfusion pressure from 5.6 ± 0.6 mmHg to 12.1 ± 1.4 mmHg. Subsequent infusion of neurokinin B significantly decreased lymphatic perfusion pressure from 11.9 ± 1.3 mmHg to 9.9 ± 1.1 mmHg. These data indicate that neurokinin A and B can alter lymphatic resistance and are consistent with the hypothesis that lymph vessel function may be subject to modulation by neurokinins.http://dx.doi.org/10.1155/S096293519200036X |
| spellingShingle | David E. Dobbins Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb Mediators of Inflammation |
| title | Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb |
| title_full | Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb |
| title_fullStr | Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb |
| title_full_unstemmed | Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb |
| title_short | Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb |
| title_sort | neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb |
| url | http://dx.doi.org/10.1155/S096293519200036X |
| work_keys_str_mv | AT davidedobbins neuropeptidemodulationoflymphaticsmoothmuscletoneinthecanineforelimb |