Exosomal Manf originated from endothelium regulated osteoclast differentiation by down-regulating NF-κB signaling pathway

Exosomal Manf originated from endothelium regulated osteoclast differentiation by down-regulating NF-κB signaling pathway

Abstract Background Endothelium-derived exosomes has been reported to enhanced osteogenesis. However, the role of endothelial exosomes on osteoclastgenesis is still unknown. Methods Human umbilical vein endothelial cells (HUVECs) were used to isolate exosomes. PBS or HUVEC-Exos were used to treat RA...

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Bibliographic Details
Main Authors: Zhilong Pi, You Wu, Xinyu Wang, Pingyue Li, Renkai Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Endothelium
Exosome
Osteoclast
NF-κB
Manf
Online Access:https://doi.org/10.1186/s13018-025-05671-w
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