HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials

HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials

Abstract HSK21542, a peripherally restricted kappa opioid receptor agonist, was evaluated for efficacy and safety in patients with postoperative pain following abdominal surgery. This was assessed in two phase 3, multicentre, randomized, double-blind, controlled trials (HSK21542-301 [ClinicalTrials....

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Main Authors: Yinbo Zhong, Younian Xu, Qian Lei, Mengchang Yang, Saiying Wang, Xiaoling Hu, Haihui Xie, Yalan Li, Zhong Qin, Zhengfeng Gu, Jiaqiang Zhang, Yuexin Wang, Jinglei Wu, Haiying Wang, Yue Ming, Zhongyuan Xia, Haoyu Zhai, Ke Jiang, Peng Zhang, Zhiping Wang, Liangrong Wang, Lin Li, Zhigang Cheng, Huayong Jiang, Guonian Wang, Jingli Chen, Zhibin Zhao, Xiangdong Chen, Min Yan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60013-y
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