Advanced Corneal Cross-Linking System with Fluorescence Dosimetry
Purpose. This paper describes an advanced system that combines corneal cross-linking with riboflavin with fluorescence dosimetry, the ability to measure riboflavin diffusion within the cornea both before and during UVA treatment. Methods and Results. A corneal cross-linking system utilizing a digita...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/303459 |
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| _version_ | 1850224536010620928 |
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| author | Marc D. Friedman Radha Pertaub David Usher Evan Sherr Pavel Kamaev David Muller |
| author_facet | Marc D. Friedman Radha Pertaub David Usher Evan Sherr Pavel Kamaev David Muller |
| author_sort | Marc D. Friedman |
| collection | DOAJ |
| description | Purpose. This paper describes an advanced system that combines corneal cross-linking with riboflavin with fluorescence dosimetry, the ability to measure riboflavin diffusion within the cornea both before and during UVA treatment. Methods and Results. A corneal cross-linking system utilizing a digital micromirror device (DMD) was assembled and used to measure diffusion coefficients of 0.1% riboflavin in 20% dextran in porcine eyes. A value of (3.3±0.2)×10−7 cm2/s was obtained for the stroma. Diffusion coefficients for the transepithelial formulation of 0.1% riboflavin in 0.44% saline and 0.02% BAK were also measured to be 4.7±0.3×10−8 cm2/s for epithelium only and (4.6±0.4)×10−7 cm2/s for stroma only. Riboflavin consumption during a UVA treatment was also demonstrated. Conclusion. A new advanced corneal cross-linking system with fluorescence dosimetry of riboflavin has been demonstrated. It is hoped that this method may play a significant role in determining the underlying mechanisms of corneal cross-linking and assist with the development of additional riboflavin formulations. Moreover, dosimetry may prove valuable in providing a method to account for the biological differences between individuals, potentially informing cornea-specific UVA treatment doses in real time. |
| format | Article |
| id | doaj-art-59d10fbd276e4889aca6d26de38fc430 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-59d10fbd276e4889aca6d26de38fc4302025-08-20T02:05:35ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/303459303459Advanced Corneal Cross-Linking System with Fluorescence DosimetryMarc D. Friedman0Radha Pertaub1David Usher2Evan Sherr3Pavel Kamaev4David Muller5Research and Development, Avedro Inc., Waltham, MA 02451, USAResearch and Development, Avedro Inc., Waltham, MA 02451, USAResearch and Development, Avedro Inc., Waltham, MA 02451, USAResearch and Development, Avedro Inc., Waltham, MA 02451, USAResearch and Development, Avedro Inc., Waltham, MA 02451, USAResearch and Development, Avedro Inc., Waltham, MA 02451, USAPurpose. This paper describes an advanced system that combines corneal cross-linking with riboflavin with fluorescence dosimetry, the ability to measure riboflavin diffusion within the cornea both before and during UVA treatment. Methods and Results. A corneal cross-linking system utilizing a digital micromirror device (DMD) was assembled and used to measure diffusion coefficients of 0.1% riboflavin in 20% dextran in porcine eyes. A value of (3.3±0.2)×10−7 cm2/s was obtained for the stroma. Diffusion coefficients for the transepithelial formulation of 0.1% riboflavin in 0.44% saline and 0.02% BAK were also measured to be 4.7±0.3×10−8 cm2/s for epithelium only and (4.6±0.4)×10−7 cm2/s for stroma only. Riboflavin consumption during a UVA treatment was also demonstrated. Conclusion. A new advanced corneal cross-linking system with fluorescence dosimetry of riboflavin has been demonstrated. It is hoped that this method may play a significant role in determining the underlying mechanisms of corneal cross-linking and assist with the development of additional riboflavin formulations. Moreover, dosimetry may prove valuable in providing a method to account for the biological differences between individuals, potentially informing cornea-specific UVA treatment doses in real time.http://dx.doi.org/10.1155/2012/303459 |
| spellingShingle | Marc D. Friedman Radha Pertaub David Usher Evan Sherr Pavel Kamaev David Muller Advanced Corneal Cross-Linking System with Fluorescence Dosimetry Journal of Ophthalmology |
| title | Advanced Corneal Cross-Linking System with Fluorescence Dosimetry |
| title_full | Advanced Corneal Cross-Linking System with Fluorescence Dosimetry |
| title_fullStr | Advanced Corneal Cross-Linking System with Fluorescence Dosimetry |
| title_full_unstemmed | Advanced Corneal Cross-Linking System with Fluorescence Dosimetry |
| title_short | Advanced Corneal Cross-Linking System with Fluorescence Dosimetry |
| title_sort | advanced corneal cross linking system with fluorescence dosimetry |
| url | http://dx.doi.org/10.1155/2012/303459 |
| work_keys_str_mv | AT marcdfriedman advancedcornealcrosslinkingsystemwithfluorescencedosimetry AT radhapertaub advancedcornealcrosslinkingsystemwithfluorescencedosimetry AT davidusher advancedcornealcrosslinkingsystemwithfluorescencedosimetry AT evansherr advancedcornealcrosslinkingsystemwithfluorescencedosimetry AT pavelkamaev advancedcornealcrosslinkingsystemwithfluorescencedosimetry AT davidmuller advancedcornealcrosslinkingsystemwithfluorescencedosimetry |