Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod
Myasthenia gravis (MG) is a neuromuscular junction disorder clinically characterized by fluctuating muscle weakness, in which some patients with respiratory muscle weakness are at risk of progressing to myasthenia gravis crisis and respiratory failure, requiring treatment with rapid antibody clearan...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526975/full |
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| author | Jia Ke Qi Zhao Na Wang Bei Zhang Jin-Quan Hu |
| author_facet | Jia Ke Qi Zhao Na Wang Bei Zhang Jin-Quan Hu |
| author_sort | Jia Ke |
| collection | DOAJ |
| description | Myasthenia gravis (MG) is a neuromuscular junction disorder clinically characterized by fluctuating muscle weakness, in which some patients with respiratory muscle weakness are at risk of progressing to myasthenia gravis crisis and respiratory failure, requiring treatment with rapid antibody clearance. Currently widely used intravenous immunoglobulin and plasma exchange therapy remains ineffective in some patients and is limited by multiple contraindications. Efgartigimod is a newly approved FcRn antagonist for the treatment of myasthenia gravis, which rapidly cleans IgG antibodies in the body, but there is still a lack of guidance on the use of efgartigimod in patients with renal insufficiency. Here, we report a case of MG patient with end-stage renal disease undergoing maintenance hemodialysis who successfully navigated a myasthenic crisis and achieved significant clinical remission through efgartigimod therapy. Moreover, sustained efgartigimod maintenance therapy enabled achievement of clinical minimum state. This case demonstrates the therapeutic potential of efgartigimod in MG patients with concomitant renal impairment and provides clinical evidence supporting its application in this special population. |
| format | Article |
| id | doaj-art-59cd9749732147cc85179c0d234dd1ec |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-59cd9749732147cc85179c0d234dd1ec2025-08-20T02:49:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15269751526975Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimodJia KeQi ZhaoNa WangBei ZhangJin-Quan HuMyasthenia gravis (MG) is a neuromuscular junction disorder clinically characterized by fluctuating muscle weakness, in which some patients with respiratory muscle weakness are at risk of progressing to myasthenia gravis crisis and respiratory failure, requiring treatment with rapid antibody clearance. Currently widely used intravenous immunoglobulin and plasma exchange therapy remains ineffective in some patients and is limited by multiple contraindications. Efgartigimod is a newly approved FcRn antagonist for the treatment of myasthenia gravis, which rapidly cleans IgG antibodies in the body, but there is still a lack of guidance on the use of efgartigimod in patients with renal insufficiency. Here, we report a case of MG patient with end-stage renal disease undergoing maintenance hemodialysis who successfully navigated a myasthenic crisis and achieved significant clinical remission through efgartigimod therapy. Moreover, sustained efgartigimod maintenance therapy enabled achievement of clinical minimum state. This case demonstrates the therapeutic potential of efgartigimod in MG patients with concomitant renal impairment and provides clinical evidence supporting its application in this special population.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526975/fullmyasthenia gravisefgartigimodhemodialysischronic kidney diseasemyasthenic crisis |
| spellingShingle | Jia Ke Qi Zhao Na Wang Bei Zhang Jin-Quan Hu Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod Frontiers in Immunology myasthenia gravis efgartigimod hemodialysis chronic kidney disease myasthenic crisis |
| title | Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod |
| title_full | Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod |
| title_fullStr | Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod |
| title_full_unstemmed | Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod |
| title_short | Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod |
| title_sort | case report a myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod |
| topic | myasthenia gravis efgartigimod hemodialysis chronic kidney disease myasthenic crisis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526975/full |
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