Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases
Inflammation, altered immune cell phenotype, and functions are key features shared by diverse chronic diseases, including cardiovascular, neurodegenerative diseases, diabetes, metabolic syndrome, and cancer. Natural killer cells are innate lymphoid cells primarily involved in the immune system respo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/4218254 |
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| _version_ | 1849412459622825984 |
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| author | Luca Parisi Barbara Bassani Marco Tremolati Elisabetta Gini Giampietro Farronato Antonino Bruno |
| author_facet | Luca Parisi Barbara Bassani Marco Tremolati Elisabetta Gini Giampietro Farronato Antonino Bruno |
| author_sort | Luca Parisi |
| collection | DOAJ |
| description | Inflammation, altered immune cell phenotype, and functions are key features shared by diverse chronic diseases, including cardiovascular, neurodegenerative diseases, diabetes, metabolic syndrome, and cancer. Natural killer cells are innate lymphoid cells primarily involved in the immune system response to non-self-components but their plasticity is largely influenced by the pathological microenvironment. Altered NK phenotype and function have been reported in several pathological conditions, basically related to impaired or enhanced toxicity. Here we reviewed and discussed the role of NKs in selected, different, and “distant” chronic diseases, cancer, diabetes, periodontitis, and atherosclerosis, placing NK cells as crucial orchestrator of these pathologic conditions. |
| format | Article |
| id | doaj-art-59c8501204514f36af3449c4948cf36f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-59c8501204514f36af3449c4948cf36f2025-08-20T03:34:26ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/42182544218254Natural Killer Cells in the Orchestration of Chronic Inflammatory DiseasesLuca Parisi0Barbara Bassani1Marco Tremolati2Elisabetta Gini3Giampietro Farronato4Antonino Bruno5Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, ItalyScientific and Technological Pole, IRCCS MultiMedica, Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, ItalyDepartment of Biotechnology and Life Sciences (DBSV), University of Insubria, Varese, ItalyDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, ItalyScientific and Technological Pole, IRCCS MultiMedica, Milan, ItalyInflammation, altered immune cell phenotype, and functions are key features shared by diverse chronic diseases, including cardiovascular, neurodegenerative diseases, diabetes, metabolic syndrome, and cancer. Natural killer cells are innate lymphoid cells primarily involved in the immune system response to non-self-components but their plasticity is largely influenced by the pathological microenvironment. Altered NK phenotype and function have been reported in several pathological conditions, basically related to impaired or enhanced toxicity. Here we reviewed and discussed the role of NKs in selected, different, and “distant” chronic diseases, cancer, diabetes, periodontitis, and atherosclerosis, placing NK cells as crucial orchestrator of these pathologic conditions.http://dx.doi.org/10.1155/2017/4218254 |
| spellingShingle | Luca Parisi Barbara Bassani Marco Tremolati Elisabetta Gini Giampietro Farronato Antonino Bruno Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases Journal of Immunology Research |
| title | Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases |
| title_full | Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases |
| title_fullStr | Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases |
| title_full_unstemmed | Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases |
| title_short | Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases |
| title_sort | natural killer cells in the orchestration of chronic inflammatory diseases |
| url | http://dx.doi.org/10.1155/2017/4218254 |
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