Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department
Background/Aim. Botulinum toxin (BTX) irreversibly inhibits presynaptic acetylcholine release with subsequent relaxation of abnormally contracting muscles. It is an effective and well tolerated treatment with long-term benefit in a variety of movement disorders and other neurological and...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500114T.pdf |
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| author | Tomić Aleksandra Vujović Balša Svetel Marina Dragašević-Mišković Nataša Petrović Igor Pekmezović Tatjana Kostić Vladimir S. |
| author_facet | Tomić Aleksandra Vujović Balša Svetel Marina Dragašević-Mišković Nataša Petrović Igor Pekmezović Tatjana Kostić Vladimir S. |
| author_sort | Tomić Aleksandra |
| collection | DOAJ |
| description | Background/Aim. Botulinum toxin (BTX) irreversibly inhibits presynaptic
acetylcholine release with subsequent relaxation of abnormally contracting
muscles. It is an effective and well tolerated treatment with long-term
benefit in a variety of movement disorders and other neurological and
non-neurological disturbances. The aim of our study was to present our
experience with BTX type A in treatment of different forms of focal
dystonias. Мethods. А hundred of patients with different focal dystonias
(spastic torticollis, blepharospasm and graphospasm) from the Botulinum Toxin
Outpatients Department, Clinic for Neurology, Clinical Center of Serbia, were
included in the study. All the patients were examined and rated at baseline
visit prior to BTX application and on the following visit, after 3-4 months,
using self-assessment improvement questionnaire and standardized rating
scales. Results. The improvement of ≥ 50% was presented in 68.2% of all (199)
the analyzed applications. Independent predictors of good response to the
therapy (improvement ≥ 50%) were male sex (p = 0.011), the presence of
sensory trick (p = 0.013) and the total number of BTX applications (p =
0.002). The patients with spastic torticollis and blepharospasm showed a
statistically significantly better BTX effect (improvement 57.3 ± 27.5% and
54.1 ± 28.3%), respectively than the graphospasm group (26.7 ± 25.6%). Most
of the patients did not have therapy complications (81.4% and 72% in two
applications). Side effects in the remaining patients (muscle weakness,
dysphagia, ptosis, double vision, neck weakness and lacrimal dysfunction)
lasted for 28.3 ± 18.6 days after the first treatment and 32.5 ± 36.2 days
after the second one. Conclusion. BTX is safe and highly effective in
long-term treatment of patients with different forms of focal dystonia, with
only mild and well-tolerated side-effects. [Projekat Ministarstva nauke
Republike Srbije, br. 175090] |
| format | Article |
| id | doaj-art-59c7bfb8a5934551823903090406c633 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-59c7bfb8a5934551823903090406c6332025-08-20T01:57:04ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202015-01-0172121069107310.2298/VSP131224114T0042-84501500114TEfficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients DepartmentTomić Aleksandra0Vujović Balša1Svetel Marina2Dragašević-Mišković Nataša3Petrović Igor4Pekmezović Tatjana5Kostić Vladimir S.6Clinical Center of Serbia, Clinic for Neurology, BelgradeClinical Center of Montenegro, Clinic for Neurology, Podgorica, MontenegroClinical Center of Serbia, Clinic for Neurology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Neurology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Neurology, Belgrade + Faculty of Medicine, BelgradeFaculty of Medicine, Institute of Epidemiology, BelgradeClinical Center of Serbia, Clinic for Neurology, Belgrade + Faculty of Medicine, BelgradeBackground/Aim. Botulinum toxin (BTX) irreversibly inhibits presynaptic acetylcholine release with subsequent relaxation of abnormally contracting muscles. It is an effective and well tolerated treatment with long-term benefit in a variety of movement disorders and other neurological and non-neurological disturbances. The aim of our study was to present our experience with BTX type A in treatment of different forms of focal dystonias. Мethods. А hundred of patients with different focal dystonias (spastic torticollis, blepharospasm and graphospasm) from the Botulinum Toxin Outpatients Department, Clinic for Neurology, Clinical Center of Serbia, were included in the study. All the patients were examined and rated at baseline visit prior to BTX application and on the following visit, after 3-4 months, using self-assessment improvement questionnaire and standardized rating scales. Results. The improvement of ≥ 50% was presented in 68.2% of all (199) the analyzed applications. Independent predictors of good response to the therapy (improvement ≥ 50%) were male sex (p = 0.011), the presence of sensory trick (p = 0.013) and the total number of BTX applications (p = 0.002). The patients with spastic torticollis and blepharospasm showed a statistically significantly better BTX effect (improvement 57.3 ± 27.5% and 54.1 ± 28.3%), respectively than the graphospasm group (26.7 ± 25.6%). Most of the patients did not have therapy complications (81.4% and 72% in two applications). Side effects in the remaining patients (muscle weakness, dysphagia, ptosis, double vision, neck weakness and lacrimal dysfunction) lasted for 28.3 ± 18.6 days after the first treatment and 32.5 ± 36.2 days after the second one. Conclusion. BTX is safe and highly effective in long-term treatment of patients with different forms of focal dystonia, with only mild and well-tolerated side-effects. [Projekat Ministarstva nauke Republike Srbije, br. 175090]http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500114T.pdfdystoniabotulinum toxinsSerbiaquestionnairesquality of life |
| spellingShingle | Tomić Aleksandra Vujović Balša Svetel Marina Dragašević-Mišković Nataša Petrović Igor Pekmezović Tatjana Kostić Vladimir S. Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department Vojnosanitetski Pregled dystonia botulinum toxins Serbia questionnaires quality of life |
| title | Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department |
| title_full | Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department |
| title_fullStr | Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department |
| title_full_unstemmed | Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department |
| title_short | Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department |
| title_sort | efficacy of botulinum toxin type a in treatment of different forms of focal dystonias in the serbian population experience of the botulinum toxin outpatients department |
| topic | dystonia botulinum toxins Serbia questionnaires quality of life |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500114T.pdf |
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