Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial Peritonitis
Objective. We aimed to assess the predictive value of the model of end-stage liver disease (MELD) in hospitalized cirrhotic patients with and without spontaneous bacterial peritonitis (SBP) and fatal outcome. Methods. A cross-sectional study included 256 consecutive patients (199 men and 57 women) d...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/539059 |
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| author | Bledar Kraja Marsela Sina Iris Mone Fatjona Pupuleku Adriana Babameto Skerdi Prifti Genc Burazeri |
| author_facet | Bledar Kraja Marsela Sina Iris Mone Fatjona Pupuleku Adriana Babameto Skerdi Prifti Genc Burazeri |
| author_sort | Bledar Kraja |
| collection | DOAJ |
| description | Objective. We aimed to assess the predictive value of the model of end-stage liver disease (MELD) in hospitalized cirrhotic patients with and without spontaneous bacterial peritonitis (SBP) and fatal outcome. Methods. A cross-sectional study included 256 consecutive patients (199 men and 57 women) diagnosed with cirrhosis and ascites who were hospitalized at the University Hospital Center in Tirana from January 2008 to December 2009. SBP was defined as a neutrophil count of ≥250 cells/mm3 in ascitic fluid. MELD score was based on laboratory parameters determined by UNOS Internet site MELD calculator. Results. In multivariable-adjusted logistic regression models controlling for age, sex, diabetes, and etiology, there was evidence of a positive association of SBP with MELD score: the odds ratio (OR) for SBP for one unit increment of MELD score was 1.06 (95% Cl = 1.021.09). MELD score was significantly higher in fatal cases than nonfatal patients (mean age-adjusted score was 32.7 versus 18.4 overall; 34.8 versus 18.0 in SBP patients, and 32.0 versus 18.5 in non-SBP patients; all P<0.001). Conclusions. In this Albanian sample of hospitalized cirrhotic patients, MELD score was confirmed as a significant predictor of both SBP and fatal outcome. |
| format | Article |
| id | doaj-art-59befdbf232140d1b5c7cee1c166ea27 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-59befdbf232140d1b5c7cee1c166ea272025-08-20T02:05:32ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/539059539059Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial PeritonitisBledar Kraja0Marsela Sina1Iris Mone2Fatjona Pupuleku3Adriana Babameto4Skerdi Prifti5Genc Burazeri6University Clinic of Gastrohepatology, University Hospital Center “Mother Theresa”, Dibra Street No. 370, Tirana, AlbaniaUniversity Clinic of Gastrohepatology, University Hospital Center “Mother Theresa”, Dibra Street No. 370, Tirana, AlbaniaDepartment of Laboratory Medicine, University Hospital Center “Mother Theresa”, Tirana, AlbaniaInstitute of Statistics (INSTAT), Tirana, AlbaniaUniversity Clinic of Gastrohepatology, University Hospital Center “Mother Theresa”, Dibra Street No. 370, Tirana, AlbaniaUniversity Clinic of Gastrohepatology, University Hospital Center “Mother Theresa”, Dibra Street No. 370, Tirana, AlbaniaDepartment of International Health, CAPHRI School for Public Health and Primary Care, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The NetherlandsObjective. We aimed to assess the predictive value of the model of end-stage liver disease (MELD) in hospitalized cirrhotic patients with and without spontaneous bacterial peritonitis (SBP) and fatal outcome. Methods. A cross-sectional study included 256 consecutive patients (199 men and 57 women) diagnosed with cirrhosis and ascites who were hospitalized at the University Hospital Center in Tirana from January 2008 to December 2009. SBP was defined as a neutrophil count of ≥250 cells/mm3 in ascitic fluid. MELD score was based on laboratory parameters determined by UNOS Internet site MELD calculator. Results. In multivariable-adjusted logistic regression models controlling for age, sex, diabetes, and etiology, there was evidence of a positive association of SBP with MELD score: the odds ratio (OR) for SBP for one unit increment of MELD score was 1.06 (95% Cl = 1.021.09). MELD score was significantly higher in fatal cases than nonfatal patients (mean age-adjusted score was 32.7 versus 18.4 overall; 34.8 versus 18.0 in SBP patients, and 32.0 versus 18.5 in non-SBP patients; all P<0.001). Conclusions. In this Albanian sample of hospitalized cirrhotic patients, MELD score was confirmed as a significant predictor of both SBP and fatal outcome.http://dx.doi.org/10.1155/2012/539059 |
| spellingShingle | Bledar Kraja Marsela Sina Iris Mone Fatjona Pupuleku Adriana Babameto Skerdi Prifti Genc Burazeri Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial Peritonitis Gastroenterology Research and Practice |
| title | Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial Peritonitis |
| title_full | Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial Peritonitis |
| title_fullStr | Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial Peritonitis |
| title_full_unstemmed | Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial Peritonitis |
| title_short | Predictive Value of the Model of End-Stage Liver Disease in Cirrhotic Patients with and without Spontaneous Bacterial Peritonitis |
| title_sort | predictive value of the model of end stage liver disease in cirrhotic patients with and without spontaneous bacterial peritonitis |
| url | http://dx.doi.org/10.1155/2012/539059 |
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