Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysis
Objective To assess the effectiveness and safety of anti-seizure medication (ASMs) for refractory partial-onset seizures.Methods The PubMed, Embase and The Cochrane Library were searched to collect randomized controlled trials (RCTs) related to ASMs for refractory partial-onset seizures from the inc...
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Editorial Office of New Medicine
2024-11-01
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| Series: | Yixue xinzhi zazhi |
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| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2412/Ncc0FjMbWKCdvqUAEeaoAU8hZoe8a2a5Gk3gfqg2.pdf |
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| author | ZHANG Chao NIU Yuming YAN Jinzhu YAO Shuting WANG Songling JIANG Hualing ZHAO Minhua |
| author_facet | ZHANG Chao NIU Yuming YAN Jinzhu YAO Shuting WANG Songling JIANG Hualing ZHAO Minhua |
| author_sort | ZHANG Chao |
| collection | DOAJ |
| description | Objective To assess the effectiveness and safety of anti-seizure medication (ASMs) for refractory partial-onset seizures.Methods The PubMed, Embase and The Cochrane Library were searched to collect randomized controlled trials (RCTs) related to ASMs for refractory partial-onset seizures from the inception of the database to November 1, 2024.Results 56 literature were included, involving 57 RCTs and 15,667 patients. Network Meta-analysis showed that when compared with placebo, tiagabine [RR=3.43, 95%CI(1.91, 6.14)], topiramate [RR=2.61, 95%CI(2.11, 3.23)], levetiracetam [RR=2.28, 95%CI(1.84, 2.83)], zonisamide [RR=2.28, 95%CI(1.70, 3.08)], rufinamide [RR=2.28, 95%CI(1.24, 4.19)], oxcarbazepine [RR=2.10, 95%CI(1.61, 2.74)], vigabatrin [RR=2.06, 95%CI(1.28, 3.30)], gabapentin [RR=2.02, 95%CI(1.51, 2.70)], pregabalin [RR=2.00, 95%CI(1.60, 2.50)], cenobamate [RR=1.97, 95%CI(1.40, 2.76)], lamotrigine [RR=1.85, 95%CI(1.09, 3.12)], lacosamide [RR=1.78, 95%CI(1.51, 2.10)], eslicarbazepine acetate [RR=1.75, 95%CI(1.43, 2.14)] and brivaracetam [RR=1.74, 95%CI(1.37, 2.21)] showed statistically significant effectiveness in achieving a 50% response rate (P |
| format | Article |
| id | doaj-art-59b64833f7ea47fd8bffc8cb71d6d078 |
| institution | OA Journals |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of New Medicine |
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| series | Yixue xinzhi zazhi |
| spelling | doaj-art-59b64833f7ea47fd8bffc8cb71d6d0782025-08-20T02:31:59ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112024-11-0134111243126510.12173/j.issn.1004-5511.2024112266561Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysisZHANG ChaoNIU YumingYAN JinzhuYAO ShutingWANG SonglingJIANG HualingZHAO MinhuaObjective To assess the effectiveness and safety of anti-seizure medication (ASMs) for refractory partial-onset seizures.Methods The PubMed, Embase and The Cochrane Library were searched to collect randomized controlled trials (RCTs) related to ASMs for refractory partial-onset seizures from the inception of the database to November 1, 2024.Results 56 literature were included, involving 57 RCTs and 15,667 patients. Network Meta-analysis showed that when compared with placebo, tiagabine [RR=3.43, 95%CI(1.91, 6.14)], topiramate [RR=2.61, 95%CI(2.11, 3.23)], levetiracetam [RR=2.28, 95%CI(1.84, 2.83)], zonisamide [RR=2.28, 95%CI(1.70, 3.08)], rufinamide [RR=2.28, 95%CI(1.24, 4.19)], oxcarbazepine [RR=2.10, 95%CI(1.61, 2.74)], vigabatrin [RR=2.06, 95%CI(1.28, 3.30)], gabapentin [RR=2.02, 95%CI(1.51, 2.70)], pregabalin [RR=2.00, 95%CI(1.60, 2.50)], cenobamate [RR=1.97, 95%CI(1.40, 2.76)], lamotrigine [RR=1.85, 95%CI(1.09, 3.12)], lacosamide [RR=1.78, 95%CI(1.51, 2.10)], eslicarbazepine acetate [RR=1.75, 95%CI(1.43, 2.14)] and brivaracetam [RR=1.74, 95%CI(1.37, 2.21)] showed statistically significant effectiveness in achieving a 50% response rate (Phttps://yxxz.whuznhmedj.com/futureApi/storage/attach/2412/Ncc0FjMbWKCdvqUAEeaoAU8hZoe8a2a5Gk3gfqg2.pdfrefractory partial-onset seizuresanti-seizure medicationtopiramatelevetiracetamgabapentinpregabalin |
| spellingShingle | ZHANG Chao NIU Yuming YAN Jinzhu YAO Shuting WANG Songling JIANG Hualing ZHAO Minhua Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysis Yixue xinzhi zazhi refractory partial-onset seizures anti-seizure medication topiramate levetiracetam gabapentin pregabalin |
| title | Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysis |
| title_full | Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysis |
| title_fullStr | Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysis |
| title_full_unstemmed | Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysis |
| title_short | Effectiveness and safety of anti-seizure medications for refractory partial-onset seizures based on network Meta-analysis |
| title_sort | effectiveness and safety of anti seizure medications for refractory partial onset seizures based on network meta analysis |
| topic | refractory partial-onset seizures anti-seizure medication topiramate levetiracetam gabapentin pregabalin |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2412/Ncc0FjMbWKCdvqUAEeaoAU8hZoe8a2a5Gk3gfqg2.pdf |
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