The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities
Atrial fibrillation (AF) is one of the most common cardiac arrhythmias encountered globally, characterized by a pro-inflammatory pattern. This analysis evaluated the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with AF alongside chronic kidney disease (CKD)...
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MDPI AG
2025-06-01
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| author | Evelina Maria Gosav Daniela Maria Tanase Anca Ouatu Oana Nicoleta Buliga-Finis Diana Popescu Cristina Gena Dascalu Nicoleta Dima Minerva Codruta Badescu Ciprian Rezus |
| author_facet | Evelina Maria Gosav Daniela Maria Tanase Anca Ouatu Oana Nicoleta Buliga-Finis Diana Popescu Cristina Gena Dascalu Nicoleta Dima Minerva Codruta Badescu Ciprian Rezus |
| author_sort | Evelina Maria Gosav |
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| description | Atrial fibrillation (AF) is one of the most common cardiac arrhythmias encountered globally, characterized by a pro-inflammatory pattern. This analysis evaluated the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with AF alongside chronic kidney disease (CKD) and/or type 2 diabetes mellitus (T2DM). This retrospective cohort study included 6077 patients admitted to the Third Medical Clinic of Saint Spiridon Hospital in Iasi from 2018 to 2023, all diagnosed with AF, CKD, and T2DM. After applying the exclusion criteria, 1066 AF patients remained eligible. For a multivariate comparative analysis, the patients were divided into groups: I. control group (non-AF patients); II. AF patients; III. T2DM group; IV. CKD-only group; V. AF+CKD group; VI. AF+T2DM group; and VII. AF+T2DM+CKD group. The Mann–Whitney/Kruskal–Wallis test demonstrated a statistically significant difference in NLR and PLR values between the AF group and the non-AF group (H = 70.627, <i>p</i> < 0.001). The receiver operating characteristic (ROC) analysis identified statistical significance and predictive power for NLR (AUC = 0.722; sensitivity = 63.6%; specificity = 76.9%) and neutrophil count in diagnosing AF, T2DM, and CKD. In conclusion, this study illustrated the utility of NLR and PLR as readily available and predictive biomarkers of inflammation in patients with AF, with or without comorbidities. |
| format | Article |
| id | doaj-art-59b2dce8259746b68752b3ba53084054 |
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| language | English |
| publishDate | 2025-06-01 |
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| series | Life |
| spelling | doaj-art-59b2dce8259746b68752b3ba530840542025-08-20T02:20:58ZengMDPI AGLife2075-17292025-06-0115696010.3390/life15060960The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its ComorbiditiesEvelina Maria Gosav0Daniela Maria Tanase1Anca Ouatu2Oana Nicoleta Buliga-Finis3Diana Popescu4Cristina Gena Dascalu5Nicoleta Dima6Minerva Codruta Badescu7Ciprian Rezus8Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Informatics and Biostatistics, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaAtrial fibrillation (AF) is one of the most common cardiac arrhythmias encountered globally, characterized by a pro-inflammatory pattern. This analysis evaluated the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with AF alongside chronic kidney disease (CKD) and/or type 2 diabetes mellitus (T2DM). This retrospective cohort study included 6077 patients admitted to the Third Medical Clinic of Saint Spiridon Hospital in Iasi from 2018 to 2023, all diagnosed with AF, CKD, and T2DM. After applying the exclusion criteria, 1066 AF patients remained eligible. For a multivariate comparative analysis, the patients were divided into groups: I. control group (non-AF patients); II. AF patients; III. T2DM group; IV. CKD-only group; V. AF+CKD group; VI. AF+T2DM group; and VII. AF+T2DM+CKD group. The Mann–Whitney/Kruskal–Wallis test demonstrated a statistically significant difference in NLR and PLR values between the AF group and the non-AF group (H = 70.627, <i>p</i> < 0.001). The receiver operating characteristic (ROC) analysis identified statistical significance and predictive power for NLR (AUC = 0.722; sensitivity = 63.6%; specificity = 76.9%) and neutrophil count in diagnosing AF, T2DM, and CKD. In conclusion, this study illustrated the utility of NLR and PLR as readily available and predictive biomarkers of inflammation in patients with AF, with or without comorbidities.https://www.mdpi.com/2075-1729/15/6/960atrial fibrillationAFneutrophil-to-lymphocyte ratioNLRplatelet-to-lymphocyte ratioPLR |
| spellingShingle | Evelina Maria Gosav Daniela Maria Tanase Anca Ouatu Oana Nicoleta Buliga-Finis Diana Popescu Cristina Gena Dascalu Nicoleta Dima Minerva Codruta Badescu Ciprian Rezus The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities Life atrial fibrillation AF neutrophil-to-lymphocyte ratio NLR platelet-to-lymphocyte ratio PLR |
| title | The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities |
| title_full | The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities |
| title_fullStr | The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities |
| title_full_unstemmed | The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities |
| title_short | The Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting Atrial Fibrillation and Its Comorbidities |
| title_sort | role of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in predicting atrial fibrillation and its comorbidities |
| topic | atrial fibrillation AF neutrophil-to-lymphocyte ratio NLR platelet-to-lymphocyte ratio PLR |
| url | https://www.mdpi.com/2075-1729/15/6/960 |
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