Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes
Abstract Hemoperfusion (HP) represents a treatment option for sepsis. This study evaluated Seraph-100 in septic patients admitted to the intensive care unit (ICU) after cardiac surgery due to infective endocarditis (IE). Thirteen septic patients were enrolled and treated by Seraph-100 hemoperfusion....
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-01280-z |
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| author | Antonio Lacquaniti Antonella Smeriglio Fabrizio Ceresa Susanna Campo Daniele Caruso Giuseppe Falliti Erminia La Camera Francesco Patané Domenico Trombetta Paolo Monardo |
| author_facet | Antonio Lacquaniti Antonella Smeriglio Fabrizio Ceresa Susanna Campo Daniele Caruso Giuseppe Falliti Erminia La Camera Francesco Patané Domenico Trombetta Paolo Monardo |
| author_sort | Antonio Lacquaniti |
| collection | DOAJ |
| description | Abstract Hemoperfusion (HP) represents a treatment option for sepsis. This study evaluated Seraph-100 in septic patients admitted to the intensive care unit (ICU) after cardiac surgery due to infective endocarditis (IE). Thirteen septic patients were enrolled and treated by Seraph-100 hemoperfusion. Fiftenne patients, not treated by HP, represented a control group. Pathogens were assessed before (T0) and after 4 h of HP treatment (T4). The difference between the two- quantification cycle (Cq) values (T0 and T4), namely ∆Cq at the polymerase chain reaction, was a surrogate marker of pathogen removal. The bacterial load decreased after Seraph-100 HP, with a mean ∆Cq values of 4.6 ± 2.4, as corroborated by conventional haemoculture’s results. Field Emission Scanning Electron Microscopy analyses confirm the Seraph’ adsorptive properties. Procalcitonin, C reactive protein and lactates significantly decreased, with a reduced ICU stay in the Seraph group. After HP, only 15% of patients had AKI requiring renal replacement therapy (RRT), significantly lower than that found in the control group (40%). The Seraph-100 HP induces a decrease of vasopressor doses, a hemodynamic stability and a reduction of AKI and RRT, improving the clinical course, reflected as a reduced ICU stay. |
| format | Article |
| id | doaj-art-59b04233eef54b94bc0249f74df506f7 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-59b04233eef54b94bc0249f74df506f72025-08-20T03:08:25ZengNature PortfolioScientific Reports2045-23222025-05-0115111310.1038/s41598-025-01280-zHemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomesAntonio Lacquaniti0Antonella Smeriglio1Fabrizio Ceresa2Susanna Campo3Daniele Caruso4Giuseppe Falliti5Erminia La Camera6Francesco Patané7Domenico Trombetta8Paolo Monardo9Nephrology and Dialysis Unit, Papardo HospitalDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaCardiac Surgery Unit, Papardo HospitalNephrology and Dialysis Unit, Papardo HospitalClinical Pathology Unit, Papardo HospitalClinical Pathology Unit, Papardo HospitalDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaCardiac Surgery Unit, Papardo HospitalDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of MessinaNephrology and Dialysis Unit, Papardo HospitalAbstract Hemoperfusion (HP) represents a treatment option for sepsis. This study evaluated Seraph-100 in septic patients admitted to the intensive care unit (ICU) after cardiac surgery due to infective endocarditis (IE). Thirteen septic patients were enrolled and treated by Seraph-100 hemoperfusion. Fiftenne patients, not treated by HP, represented a control group. Pathogens were assessed before (T0) and after 4 h of HP treatment (T4). The difference between the two- quantification cycle (Cq) values (T0 and T4), namely ∆Cq at the polymerase chain reaction, was a surrogate marker of pathogen removal. The bacterial load decreased after Seraph-100 HP, with a mean ∆Cq values of 4.6 ± 2.4, as corroborated by conventional haemoculture’s results. Field Emission Scanning Electron Microscopy analyses confirm the Seraph’ adsorptive properties. Procalcitonin, C reactive protein and lactates significantly decreased, with a reduced ICU stay in the Seraph group. After HP, only 15% of patients had AKI requiring renal replacement therapy (RRT), significantly lower than that found in the control group (40%). The Seraph-100 HP induces a decrease of vasopressor doses, a hemodynamic stability and a reduction of AKI and RRT, improving the clinical course, reflected as a reduced ICU stay.https://doi.org/10.1038/s41598-025-01280-zSeraph-100HemoperfusionSepsisAKIICU stay |
| spellingShingle | Antonio Lacquaniti Antonella Smeriglio Fabrizio Ceresa Susanna Campo Daniele Caruso Giuseppe Falliti Erminia La Camera Francesco Patané Domenico Trombetta Paolo Monardo Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes Scientific Reports Seraph-100 Hemoperfusion Sepsis AKI ICU stay |
| title | Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes |
| title_full | Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes |
| title_fullStr | Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes |
| title_full_unstemmed | Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes |
| title_short | Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes |
| title_sort | hemoperfusion with seraph 100 in septic patients removes pathogens and improves clinical outcomes |
| topic | Seraph-100 Hemoperfusion Sepsis AKI ICU stay |
| url | https://doi.org/10.1038/s41598-025-01280-z |
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