The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Abstract Fibrosis, characterized by abnormal deposition of structural proteins, is a major cause of tissue dysfunction in chronic diseases. The disease burden associated with progressive fibrosis is substantial, and currently approved drugs are unable to effectively reverse it. Immune cells are incr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-08-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202505067 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849233251788390400 |
|---|---|
| author | Xiangqi Chen Chuan Wu Fei Tang Jingyue Zhou Li Mo Yanping Li Jinhan He |
| author_facet | Xiangqi Chen Chuan Wu Fei Tang Jingyue Zhou Li Mo Yanping Li Jinhan He |
| author_sort | Xiangqi Chen |
| collection | DOAJ |
| description | Abstract Fibrosis, characterized by abnormal deposition of structural proteins, is a major cause of tissue dysfunction in chronic diseases. The disease burden associated with progressive fibrosis is substantial, and currently approved drugs are unable to effectively reverse it. Immune cells are increasingly recognized as crucial regulators in the pathological process of fibrosis by releasing effector molecules, such as cytokines, chemokines, extracellular vesicles, metabolites, proteases, or intercellular contact. Therefore, targeting the immune microenvironment can be a potential strategy for fibrosis reduction and reversion. This review summarizes the recent advances in the understanding of the immune microenvironment in fibrosis including phenotypic and functional transformations of immune cells and the interaction of immune cells with other cells. The novel opportunities for the discovery and development of drugs for immune microenvironment remodeling and their associated challenges are also discussed. |
| format | Article |
| id | doaj-art-59aeba0ac9b148cbafac37e1e77cca17 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-59aeba0ac9b148cbafac37e1e77cca172025-08-20T11:56:10ZengWileyAdvanced Science2198-38442025-08-011230n/an/a10.1002/advs.202505067The Immune Microenvironment: New Therapeutic Implications in Organ FibrosisXiangqi Chen0Chuan Wu1Fei Tang2Jingyue Zhou3Li Mo4Yanping Li5Jinhan He6Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital Sichuan University Chengdu 610041 ChinaState Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 ChinaState Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 ChinaState Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu 610041 ChinaCenter of Gerontology and Geriatrics, West China Hospital Sichuan University Chengdu 610041 ChinaDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital Sichuan University Chengdu 610041 ChinaDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital Sichuan University Chengdu 610041 ChinaAbstract Fibrosis, characterized by abnormal deposition of structural proteins, is a major cause of tissue dysfunction in chronic diseases. The disease burden associated with progressive fibrosis is substantial, and currently approved drugs are unable to effectively reverse it. Immune cells are increasingly recognized as crucial regulators in the pathological process of fibrosis by releasing effector molecules, such as cytokines, chemokines, extracellular vesicles, metabolites, proteases, or intercellular contact. Therefore, targeting the immune microenvironment can be a potential strategy for fibrosis reduction and reversion. This review summarizes the recent advances in the understanding of the immune microenvironment in fibrosis including phenotypic and functional transformations of immune cells and the interaction of immune cells with other cells. The novel opportunities for the discovery and development of drugs for immune microenvironment remodeling and their associated challenges are also discussed.https://doi.org/10.1002/advs.202505067immune microenvironmentorgan fibrosistherapeutic targets |
| spellingShingle | Xiangqi Chen Chuan Wu Fei Tang Jingyue Zhou Li Mo Yanping Li Jinhan He The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis Advanced Science immune microenvironment organ fibrosis therapeutic targets |
| title | The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis |
| title_full | The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis |
| title_fullStr | The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis |
| title_full_unstemmed | The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis |
| title_short | The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis |
| title_sort | immune microenvironment new therapeutic implications in organ fibrosis |
| topic | immune microenvironment organ fibrosis therapeutic targets |
| url | https://doi.org/10.1002/advs.202505067 |
| work_keys_str_mv | AT xiangqichen theimmunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT chuanwu theimmunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT feitang theimmunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT jingyuezhou theimmunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT limo theimmunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT yanpingli theimmunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT jinhanhe theimmunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT xiangqichen immunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT chuanwu immunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT feitang immunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT jingyuezhou immunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT limo immunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT yanpingli immunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis AT jinhanhe immunemicroenvironmentnewtherapeuticimplicationsinorganfibrosis |