Smart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and Toxicity
The main objective of the study is to prepare smart drug delivery systems based on single-wall carbon nanotubes. In this study, nanocurcumin (N.Cur) was loaded onto SWCNTs containing polyethylene glycol (PEG) and polyethyleneimine (PEI), which includes amino groups — this led to the successful produ...
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| Format: | Article |
| Language: | English |
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College of science, university of Diyala
2023-01-01
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| Series: | Academic Science Journal |
| Online Access: | https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/52 |
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| author | Marwa R. Jwameer Sabah A. Salman Farah T. M. Noori |
| author_facet | Marwa R. Jwameer Sabah A. Salman Farah T. M. Noori |
| author_sort | Marwa R. Jwameer |
| collection | DOAJ |
| description | The main objective of the study is to prepare smart drug delivery systems based on single-wall carbon nanotubes. In this study, nanocurcumin (N.Cur) was loaded onto SWCNTs containing polyethylene glycol (PEG) and polyethyleneimine (PEI), which includes amino groups — this led to the successful production of PEG-PEI-SWCNTs. XRD, UV-Vis, and TEM techniques were employed to investigate the spectral and structural properties of (PEG-PEI-SWCNTs-N.Cur). The PEG-PEI-SWCNTs showed distinct crystalline structures and flaws, as well as a larger interlayer spacing, as evidenced by XRD patterns. After loading N. Cur, TEM analysis confirmed the presence of curcumin extract. UV-Vis absorbance peaks at 289, 300.98, (282,425), and (273,431) nm appear to be linked to SWCNTs, PEG-PEI-SWCNTs, N. Curcumin extract, and PEG-PEI-SWCNTs-N, respectively. After exposure to a variety of produced SWNTs and PEG-PEI-SWCNTs at concentrations ranging from 6.25 to 100 g/ml for 72 hours, the rate of growth inhibition in cancer cells including the liver cancer HepG2 cell line—was assessed. The cancer cells were found to be very dangerous by the cytotoxicity testing.
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| format | Article |
| id | doaj-art-59ad992012cb439dbfb7e4b32821a64a |
| institution | Kabale University |
| issn | 2958-4612 2959-5568 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | College of science, university of Diyala |
| record_format | Article |
| series | Academic Science Journal |
| spelling | doaj-art-59ad992012cb439dbfb7e4b32821a64a2024-11-19T10:02:42ZengCollege of science, university of DiyalaAcademic Science Journal2958-46122959-55682023-01-011110.24237/ASJ.01.01.632CSmart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and ToxicityMarwa R. JwameerSabah A. SalmanFarah T. M. NooriThe main objective of the study is to prepare smart drug delivery systems based on single-wall carbon nanotubes. In this study, nanocurcumin (N.Cur) was loaded onto SWCNTs containing polyethylene glycol (PEG) and polyethyleneimine (PEI), which includes amino groups — this led to the successful production of PEG-PEI-SWCNTs. XRD, UV-Vis, and TEM techniques were employed to investigate the spectral and structural properties of (PEG-PEI-SWCNTs-N.Cur). The PEG-PEI-SWCNTs showed distinct crystalline structures and flaws, as well as a larger interlayer spacing, as evidenced by XRD patterns. After loading N. Cur, TEM analysis confirmed the presence of curcumin extract. UV-Vis absorbance peaks at 289, 300.98, (282,425), and (273,431) nm appear to be linked to SWCNTs, PEG-PEI-SWCNTs, N. Curcumin extract, and PEG-PEI-SWCNTs-N, respectively. After exposure to a variety of produced SWNTs and PEG-PEI-SWCNTs at concentrations ranging from 6.25 to 100 g/ml for 72 hours, the rate of growth inhibition in cancer cells including the liver cancer HepG2 cell line—was assessed. The cancer cells were found to be very dangerous by the cytotoxicity testing. https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/52 |
| spellingShingle | Marwa R. Jwameer Sabah A. Salman Farah T. M. Noori Smart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and Toxicity Academic Science Journal |
| title | Smart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and Toxicity |
| title_full | Smart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and Toxicity |
| title_fullStr | Smart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and Toxicity |
| title_full_unstemmed | Smart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and Toxicity |
| title_short | Smart Drug Delivery Systems Based on Single-Wall Carbon Nanotubes Loaded with Nanocurcumin Extract for Cancer Therapy and Toxicity |
| title_sort | smart drug delivery systems based on single wall carbon nanotubes loaded with nanocurcumin extract for cancer therapy and toxicity |
| url | https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/52 |
| work_keys_str_mv | AT marwarjwameer smartdrugdeliverysystemsbasedonsinglewallcarbonnanotubesloadedwithnanocurcuminextractforcancertherapyandtoxicity AT sabahasalman smartdrugdeliverysystemsbasedonsinglewallcarbonnanotubesloadedwithnanocurcuminextractforcancertherapyandtoxicity AT farahtmnoori smartdrugdeliverysystemsbasedonsinglewallcarbonnanotubesloadedwithnanocurcuminextractforcancertherapyandtoxicity |