Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic Osteoarthropathy
Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy (PHO), also known as the Touraine–Solente–Gole syndrome, is an autosomal dominant genetic disorder that is rare and is identified by finger clubbing, skin thickening, and periosteal growth. This case study details the case of a 2...
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Dow University of Health Sciences
2025-03-01
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| Series: | Journal of the Dow University of Health Sciences |
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| Online Access: | https://mail.jduhs.com/index.php/jduhs/article/view/2209 |
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| author | Fatima Khurshid Kinza Shahid Randhawa Fatima Khurshid Memoona Khalid |
| author_facet | Fatima Khurshid Kinza Shahid Randhawa Fatima Khurshid Memoona Khalid |
| author_sort | Fatima Khurshid |
| collection | DOAJ |
| description |
Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy (PHO), also known as the
Touraine–Solente–Gole syndrome, is an autosomal dominant genetic disorder that is rare and is identified by finger clubbing, skin thickening, and periosteal growth. This case study details the case of a 21-year-old man with PDP to raise awareness, improve diagnosis, and enhance management strategies for the condition. The individual showed common signs like digital clubbing, pachydermia, and periostosis, as well as related symptoms like hyperhidrosis. Radiological imaging supported the diagnosis by revealing periosteal reactions and cortical thickening in multiple bones. Other conditions with comparable clinical characteristics were considered in the differential diagnosis, however, the diagnosis of PHO was confirmed by the specific radiological results and normal hormonal levels. The treatment primarily targets alleviating symptoms with drugs like Non steroidal antiinflamatory drugs (NSAIDs) and corticosteroids, along with newer options such as bisphosphonates. Timely detection and correct treatment are essential to enhance the well-being of people with PHO. This case study emphasizes the significance of tracking symptoms and offering thorough care to those with PDP/PHO.
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| format | Article |
| id | doaj-art-59aae96d39904ca693b3f1ceafb6497a |
| institution | Kabale University |
| issn | 1995-2198 2410-2180 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj-art-59aae96d39904ca693b3f1ceafb6497a2025-08-20T03:42:28ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802025-03-01409Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic OsteoarthropathyFatima Khurshid0Kinza Shahid Randhawa1Fatima Khurshid2Memoona Khalid3 Department of Medicine and Rehumatology, Ali Fatima Hospital, Lahore, Pakistan.Department of Medicine, Ali Fatima Hospital, Lahore, Pakistan.Department of Radiation and Oncology, Shifa International Hospital, Islambad, Pakistan.Department of Radiology, Ali Fatima Hospital, Lahore, Pakistan. Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy (PHO), also known as the Touraine–Solente–Gole syndrome, is an autosomal dominant genetic disorder that is rare and is identified by finger clubbing, skin thickening, and periosteal growth. This case study details the case of a 21-year-old man with PDP to raise awareness, improve diagnosis, and enhance management strategies for the condition. The individual showed common signs like digital clubbing, pachydermia, and periostosis, as well as related symptoms like hyperhidrosis. Radiological imaging supported the diagnosis by revealing periosteal reactions and cortical thickening in multiple bones. Other conditions with comparable clinical characteristics were considered in the differential diagnosis, however, the diagnosis of PHO was confirmed by the specific radiological results and normal hormonal levels. The treatment primarily targets alleviating symptoms with drugs like Non steroidal antiinflamatory drugs (NSAIDs) and corticosteroids, along with newer options such as bisphosphonates. Timely detection and correct treatment are essential to enhance the well-being of people with PHO. This case study emphasizes the significance of tracking symptoms and offering thorough care to those with PDP/PHO. https://mail.jduhs.com/index.php/jduhs/article/view/2209Digital ClubbingPrimary Hypertrophic OsteoarthropathyPachydermoperiostosisPeriostosisTouraine-Solente-Gole Syndrome |
| spellingShingle | Fatima Khurshid Kinza Shahid Randhawa Fatima Khurshid Memoona Khalid Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic Osteoarthropathy Journal of the Dow University of Health Sciences Digital Clubbing Primary Hypertrophic Osteoarthropathy Pachydermoperiostosis Periostosis Touraine-Solente-Gole Syndrome |
| title | Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic Osteoarthropathy |
| title_full | Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic Osteoarthropathy |
| title_fullStr | Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic Osteoarthropathy |
| title_full_unstemmed | Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic Osteoarthropathy |
| title_short | Pachydermoperiostosis (Touraine-Solente-Gole Syndrome): A Case Report of Primary Hypertrophic Osteoarthropathy |
| title_sort | pachydermoperiostosis touraine solente gole syndrome a case report of primary hypertrophic osteoarthropathy |
| topic | Digital Clubbing Primary Hypertrophic Osteoarthropathy Pachydermoperiostosis Periostosis Touraine-Solente-Gole Syndrome |
| url | https://mail.jduhs.com/index.php/jduhs/article/view/2209 |
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