Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion
Objectives: Evaluation of effectiveness of bioactive glass, self-assembling peptide (P11-4), and arginine bicarbonate remineralizing agents on simulated carious lesion. Material and Methods: This research was conducted using 40 human premolar teeth that had just been removed. Remineralization of dem...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_898_24 |
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| author | Rashmi P Yadahalli Yazeed Abdullah Alotaibi Ravinder Singh Mohammed Najmuddin Mohamed Tharwat Salama Radha Prasanna Dalai Noura Alessa Vardarajula Venkat Ramaiah |
| author_facet | Rashmi P Yadahalli Yazeed Abdullah Alotaibi Ravinder Singh Mohammed Najmuddin Mohamed Tharwat Salama Radha Prasanna Dalai Noura Alessa Vardarajula Venkat Ramaiah |
| author_sort | Rashmi P Yadahalli |
| collection | DOAJ |
| description | Objectives:
Evaluation of effectiveness of bioactive glass, self-assembling peptide (P11-4), and arginine bicarbonate remineralizing agents on simulated carious lesion.
Material and Methods:
This research was conducted using 40 human premolar teeth that had just been removed. Remineralization of demineralized teeth was carried out three times a day for 14 days for 5 minutes using the appropriate remineralizing agents (Group A: calcium sodium phosphosilicate (bioactive glass), Group B: self-assembling peptide (P11-4), Group C: arginine bicarbonate remineralizing agents, and control group: Group D: deionized water). Using the Vickers hardness number, the degree of demineralization and remineralization was assessed.
Results:
In every group, there was a drop in microhardness from the baseline to demineralization. In all three test groups, the shift in microhardness values from demineralization to remineralization was shown to be statistically significant.
Conclusion:
Higher remineralizing capacity was found in bioactive glass and self-assembling peptide (P11-4), which can be employed therapeutically to treat early carious lesions. |
| format | Article |
| id | doaj-art-59a8b765394a4abbbd2d292506a21c74 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-59a8b765394a4abbbd2d292506a21c742025-01-13T10:00:57ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3506S350810.4103/jpbs.jpbs_898_24Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious LesionRashmi P YadahalliYazeed Abdullah AlotaibiRavinder SinghMohammed NajmuddinMohamed Tharwat SalamaRadha Prasanna DalaiNoura AlessaVardarajula Venkat RamaiahObjectives: Evaluation of effectiveness of bioactive glass, self-assembling peptide (P11-4), and arginine bicarbonate remineralizing agents on simulated carious lesion. Material and Methods: This research was conducted using 40 human premolar teeth that had just been removed. Remineralization of demineralized teeth was carried out three times a day for 14 days for 5 minutes using the appropriate remineralizing agents (Group A: calcium sodium phosphosilicate (bioactive glass), Group B: self-assembling peptide (P11-4), Group C: arginine bicarbonate remineralizing agents, and control group: Group D: deionized water). Using the Vickers hardness number, the degree of demineralization and remineralization was assessed. Results: In every group, there was a drop in microhardness from the baseline to demineralization. In all three test groups, the shift in microhardness values from demineralization to remineralization was shown to be statistically significant. Conclusion: Higher remineralizing capacity was found in bioactive glass and self-assembling peptide (P11-4), which can be employed therapeutically to treat early carious lesions.https://journals.lww.com/10.4103/jpbs.jpbs_898_24arginine bicarbonatebioactive glassdental cariesremineralizationself-assembling peptide (p11-4) |
| spellingShingle | Rashmi P Yadahalli Yazeed Abdullah Alotaibi Ravinder Singh Mohammed Najmuddin Mohamed Tharwat Salama Radha Prasanna Dalai Noura Alessa Vardarajula Venkat Ramaiah Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion Journal of Pharmacy and Bioallied Sciences arginine bicarbonate bioactive glass dental caries remineralization self-assembling peptide (p11-4) |
| title | Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion |
| title_full | Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion |
| title_fullStr | Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion |
| title_full_unstemmed | Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion |
| title_short | Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion |
| title_sort | comparative evaluation of efficacy of self assembling peptide p11 4 bioactive glass and arginine bicarbonate remineralizing agents on simulated carious lesion |
| topic | arginine bicarbonate bioactive glass dental caries remineralization self-assembling peptide (p11-4) |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_898_24 |
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