Case series of dermopathy in autoimmune thyroid disease
Graves' disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. The clinical manifestations are a result of the impact of TSH receptor antibodies. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermat...
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Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor
2024-01-01
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| Series: | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2024/1821-19252495065J.pdf |
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| author | Janić Tamara Stojković Mirjana Marković Bojan Đurković Ivana Babić Jovana Joksimović Nata Nedeljković-Beleslin Biljana Ćirić Jasmina Žarković Miloš |
| author_facet | Janić Tamara Stojković Mirjana Marković Bojan Đurković Ivana Babić Jovana Joksimović Nata Nedeljković-Beleslin Biljana Ćirić Jasmina Žarković Miloš |
| author_sort | Janić Tamara |
| collection | DOAJ |
| description | Graves' disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. The clinical manifestations are a result of the impact of TSH receptor antibodies. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermatopathy and acropachy can also occur. Extrathyroidal manifestations of GD are most often the result of a more pronounced immune response. Dermatopathy is a rare extrathyroidal manifestation, with a prevalence of 0.5-4.3%, and when it occurs, it almost always accompanies orbitopathy (96%) and hyperthyroidism, while it is associated with a severe form of orbitopathy in 13-15% of cases. It is characteristic of long-standing disease and an intense autoimmune response. We present a case series of five patients with dysthyroid dermopathy. Our patients had different thyroid function disorders (hypo/hyperthyroidism), different forms of dermopathy, and varying times of onset during the disease. Association with orbitopathy and high TRAb concentrations were also present in all our patients. The effects of therapy applied for orbitopathy were monitored, which showed a favorable response on dermopathy, especially with the use of tocilizumab in some of our patients. |
| format | Article |
| id | doaj-art-59a82ca4a1c54583973180a1e60b0301 |
| institution | Kabale University |
| issn | 1821-1925 2406-131X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor |
| record_format | Article |
| series | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
| spelling | doaj-art-59a82ca4a1c54583973180a1e60b03012025-01-08T16:29:20ZengSpecijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma ZlatiborMedicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"1821-19252406-131X2024-01-012995657810.5937/mgiszm2495065J1821-19252495065JCase series of dermopathy in autoimmune thyroid diseaseJanić Tamara0Stojković Mirjana1https://orcid.org/0000-0003-0390-3726Marković Bojan2Đurković Ivana3Babić Jovana4Joksimović Nata5Nedeljković-Beleslin Biljana6https://orcid.org/0000-0002-1687-9297Ćirić Jasmina7Žarković Miloš8https://orcid.org/0000-0001-9977-5970Univerzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaUniverzitetski klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Odeljenje za bolesti štitaste žlezde, Beograd, SerbiaGraves' disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. The clinical manifestations are a result of the impact of TSH receptor antibodies. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermatopathy and acropachy can also occur. Extrathyroidal manifestations of GD are most often the result of a more pronounced immune response. Dermatopathy is a rare extrathyroidal manifestation, with a prevalence of 0.5-4.3%, and when it occurs, it almost always accompanies orbitopathy (96%) and hyperthyroidism, while it is associated with a severe form of orbitopathy in 13-15% of cases. It is characteristic of long-standing disease and an intense autoimmune response. We present a case series of five patients with dysthyroid dermopathy. Our patients had different thyroid function disorders (hypo/hyperthyroidism), different forms of dermopathy, and varying times of onset during the disease. Association with orbitopathy and high TRAb concentrations were also present in all our patients. The effects of therapy applied for orbitopathy were monitored, which showed a favorable response on dermopathy, especially with the use of tocilizumab in some of our patients.https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2024/1821-19252495065J.pdfdermopathyorbitopathyhyperthyroidismgraves' diseaseelephantiasispretibial myxedematrabglycosaminoglycansthyroid gland |
| spellingShingle | Janić Tamara Stojković Mirjana Marković Bojan Đurković Ivana Babić Jovana Joksimović Nata Nedeljković-Beleslin Biljana Ćirić Jasmina Žarković Miloš Case series of dermopathy in autoimmune thyroid disease Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" dermopathy orbitopathy hyperthyroidism graves' disease elephantiasis pretibial myxedema trab glycosaminoglycans thyroid gland |
| title | Case series of dermopathy in autoimmune thyroid disease |
| title_full | Case series of dermopathy in autoimmune thyroid disease |
| title_fullStr | Case series of dermopathy in autoimmune thyroid disease |
| title_full_unstemmed | Case series of dermopathy in autoimmune thyroid disease |
| title_short | Case series of dermopathy in autoimmune thyroid disease |
| title_sort | case series of dermopathy in autoimmune thyroid disease |
| topic | dermopathy orbitopathy hyperthyroidism graves' disease elephantiasis pretibial myxedema trab glycosaminoglycans thyroid gland |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2024/1821-19252495065J.pdf |
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