Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives
Abstract Netrin‐1 and B‐cell maturation antigen (BCMA) are currently being evaluated as therapeutic targets in oncology. However, studies investigating their expression in mature human lymphoid malignancies are sparse. This study aimed to investigate the expression of BCMA and Netrin‐1 in a large co...
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| Format: | Article |
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Wiley
2025-05-01
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| Series: | The Journal of Pathology: Clinical Research |
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| Online Access: | https://doi.org/10.1002/2056-4538.70027 |
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| author | Marie Donzel Alexis Trecourt Hervé Ghesquières Thi‐Thuy‐Trinh Nguyen Sara Dandash Morgane Denis Emeline Cros‐Perrial Juliette Fontaine Charles Dumontet Alexandra Traverse‐Glehen |
| author_facet | Marie Donzel Alexis Trecourt Hervé Ghesquières Thi‐Thuy‐Trinh Nguyen Sara Dandash Morgane Denis Emeline Cros‐Perrial Juliette Fontaine Charles Dumontet Alexandra Traverse‐Glehen |
| author_sort | Marie Donzel |
| collection | DOAJ |
| description | Abstract Netrin‐1 and B‐cell maturation antigen (BCMA) are currently being evaluated as therapeutic targets in oncology. However, studies investigating their expression in mature human lymphoid malignancies are sparse. This study aimed to investigate the expression of BCMA and Netrin‐1 in a large cohort of lymphomas to determine their potential role as biomarkers or therapeutic targets. BCMA and Netrin‐1 expression was investigated comprehensively using immunohistochemistry in a cohort that included 261 B‐cell lymphomas, 45 T‐cell lymphomas, and 55 classical Hodgkin lymphomas. Netrin‐1 displayed a cytoplasmic staining pattern in plasmablastic lymphomas (27/28, 96%) and classical Hodgkin lymphomas (8/55, 15%). BCMA displayed cytoplasmic staining in most plasmablastic lymphomas (17/20, 85%). Among mature B‐cell lymphomas, Netrin‐1 and BCMA displayed sensitive (96% and 85%, respectively) and specific (100% and 95%, respectively) staining in plasmablastic lymphomas. These results suggest that these proteins may help pathologists in complex diagnoses and reinforce the interest in developing clinical trials assessing Netrin‐1 or BCMA‐targeted therapies in plasmablastic lymphoma and classical Hodgkin lymphomas, for which our therapeutic arsenal is weak. |
| format | Article |
| id | doaj-art-59a7dd97ba014cdeb740e7eaf1a14c2d |
| institution | DOAJ |
| issn | 2056-4538 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Pathology: Clinical Research |
| spelling | doaj-art-59a7dd97ba014cdeb740e7eaf1a14c2d2025-08-20T03:12:27ZengWileyThe Journal of Pathology: Clinical Research2056-45382025-05-01113n/an/a10.1002/2056-4538.70027Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectivesMarie Donzel0Alexis Trecourt1Hervé Ghesquières2Thi‐Thuy‐Trinh Nguyen3Sara Dandash4Morgane Denis5Emeline Cros‐Perrial6Juliette Fontaine7Charles Dumontet8Alexandra Traverse‐Glehen9Hospices Civils de Lyon Institut de pathologie multisite, Hôpital Lyon Sud Lyon FranceHospices Civils de Lyon Institut de pathologie multisite, Hôpital Lyon Sud Lyon FranceUniversité Claude Bernard Lyon 1 Lyon FranceUniversité Claude Bernard Lyon 1 Lyon FranceUniversité Claude Bernard Lyon 1 Lyon FranceHospices Civils de Lyon, service d'hématologie Hôpital Lyon Sud Lyon FranceCancer Research Center of Lyon (CRCL) INSERM 1052/CNRS 5286/University of Lyon Lyon FranceHospices Civils de Lyon Institut de pathologie multisite, Hôpital Lyon Sud Lyon FranceUniversité Claude Bernard Lyon 1 Lyon FranceHospices Civils de Lyon Institut de pathologie multisite, Hôpital Lyon Sud Lyon FranceAbstract Netrin‐1 and B‐cell maturation antigen (BCMA) are currently being evaluated as therapeutic targets in oncology. However, studies investigating their expression in mature human lymphoid malignancies are sparse. This study aimed to investigate the expression of BCMA and Netrin‐1 in a large cohort of lymphomas to determine their potential role as biomarkers or therapeutic targets. BCMA and Netrin‐1 expression was investigated comprehensively using immunohistochemistry in a cohort that included 261 B‐cell lymphomas, 45 T‐cell lymphomas, and 55 classical Hodgkin lymphomas. Netrin‐1 displayed a cytoplasmic staining pattern in plasmablastic lymphomas (27/28, 96%) and classical Hodgkin lymphomas (8/55, 15%). BCMA displayed cytoplasmic staining in most plasmablastic lymphomas (17/20, 85%). Among mature B‐cell lymphomas, Netrin‐1 and BCMA displayed sensitive (96% and 85%, respectively) and specific (100% and 95%, respectively) staining in plasmablastic lymphomas. These results suggest that these proteins may help pathologists in complex diagnoses and reinforce the interest in developing clinical trials assessing Netrin‐1 or BCMA‐targeted therapies in plasmablastic lymphoma and classical Hodgkin lymphomas, for which our therapeutic arsenal is weak.https://doi.org/10.1002/2056-4538.70027BCMANetrin‐1immunocytochemistrylymphomaplasmablasticlymphoma |
| spellingShingle | Marie Donzel Alexis Trecourt Hervé Ghesquières Thi‐Thuy‐Trinh Nguyen Sara Dandash Morgane Denis Emeline Cros‐Perrial Juliette Fontaine Charles Dumontet Alexandra Traverse‐Glehen Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives The Journal of Pathology: Clinical Research BCMA Netrin‐1 immunocytochemistry lymphoma plasmablastic lymphoma |
| title | Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives |
| title_full | Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives |
| title_fullStr | Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives |
| title_full_unstemmed | Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives |
| title_short | Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives |
| title_sort | netrin 1 and b cell maturation antigen expression in a large cohort of 361 lymphomas sensitive and specific staining in plasmablastic lymphomas and therapeutic perspectives |
| topic | BCMA Netrin‐1 immunocytochemistry lymphoma plasmablastic lymphoma |
| url | https://doi.org/10.1002/2056-4538.70027 |
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