Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life
Introduction. In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (asses...
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2021-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2021/8871549 |
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| author | D. Santos García T. De Deus Fonticoba J. M. Paz González C. Cores Bartolomé L. Valdés Aymerich J. G. Muñoz Enríquez E. Suárez S. Jesús M. Aguilar P. Pastor L. L. Planellas M. Cosgaya J. García Caldentey N. Caballol I. Legarda J. Hernández Vara I. Cabo L. López Manzanares I. González Aramburu M. A. Ávila Rivera M. J. Catalán V. Nogueira V. Puente J. M. García Moreno C. Borrué B. Solano Vila M. Álvarez Sauco L. Vela S. Escalante E. Cubo F. Carrillo Padilla J. C. Martínez Castrillo P. Sánchez Alonso M. G. Alonso Losada N. López Ariztegui I. Gastón J. Kulisevsky M. Blázquez Estrada M. Seijo J. Rúiz Martínez C. Valero M. Kurtis O. de Fábregues J. González Ardura C. Ordás L. López Díaz P. Mir P. Martinez-Martin COPPADIS Study Group |
| author_facet | D. Santos García T. De Deus Fonticoba J. M. Paz González C. Cores Bartolomé L. Valdés Aymerich J. G. Muñoz Enríquez E. Suárez S. Jesús M. Aguilar P. Pastor L. L. Planellas M. Cosgaya J. García Caldentey N. Caballol I. Legarda J. Hernández Vara I. Cabo L. López Manzanares I. González Aramburu M. A. Ávila Rivera M. J. Catalán V. Nogueira V. Puente J. M. García Moreno C. Borrué B. Solano Vila M. Álvarez Sauco L. Vela S. Escalante E. Cubo F. Carrillo Padilla J. C. Martínez Castrillo P. Sánchez Alonso M. G. Alonso Losada N. López Ariztegui I. Gastón J. Kulisevsky M. Blázquez Estrada M. Seijo J. Rúiz Martínez C. Valero M. Kurtis O. de Fábregues J. González Ardura C. Ordás L. López Díaz P. Mir P. Martinez-Martin COPPADIS Study Group |
| author_sort | D. Santos García |
| collection | DOAJ |
| description | Introduction. In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient’s quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0–20; B: NMSS = 21–40; C: NMSS = 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p<0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p<0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p<0.0001). Conclusion. The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden. |
| format | Article |
| id | doaj-art-59a6353979e04f60ae4c6dfc6d5fa628 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-59a6353979e04f60ae4c6dfc6d5fa6282025-08-20T03:34:40ZengWileyParkinson's Disease2090-80832042-00802021-01-01202110.1155/2021/88715498871549Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of LifeD. Santos García0T. De Deus Fonticoba1J. M. Paz González2C. Cores Bartolomé3L. Valdés Aymerich4J. G. Muñoz Enríquez5E. Suárez6S. Jesús7M. Aguilar8P. Pastor9L. L. Planellas10M. Cosgaya11J. García Caldentey12N. Caballol13I. Legarda14J. Hernández Vara15I. Cabo16L. López Manzanares17I. González Aramburu18M. A. Ávila Rivera19M. J. Catalán20V. Nogueira21V. Puente22J. M. García Moreno23C. Borrué24B. Solano Vila25M. Álvarez Sauco26L. Vela27S. Escalante28E. Cubo29F. Carrillo Padilla30J. C. Martínez Castrillo31P. Sánchez Alonso32M. G. Alonso Losada33N. López Ariztegui34I. Gastón35J. Kulisevsky36M. Blázquez Estrada37M. Seijo38J. Rúiz Martínez39C. Valero40M. Kurtis41O. de Fábregues42J. González Ardura43C. Ordás44L. López Díaz45P. Mir46P. Martinez-Martin47COPPADIS Study Group48CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, SpainCHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, SpainCHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, SpainCHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, SpainCHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, SpainCHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, SpainCHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, SpainUnidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, SpainHospital Universitari Mutua de Terrassa, Terrassa, SpainHospital Universitari Mutua de Terrassa, Terrassa, SpainHospital Clínic de Barcelona, Barcelona, SpainHospital Clínic de Barcelona, Barcelona, SpainCentro Neurológico Oms 42, Palma de Mallorca, SpainConsorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, SpainHospital Universitario Son Espases, Palma de Mallorca, SpainHospital Universitario Vall d´Hebron, Barcelona, SpainComplejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, SpainHospital Universitario La Princesa, Madrid, SpainCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Madrid, SpainConsorci Sanitari Integral, Hospital General de L´Hospitalet, L´Hospitalet de Llobregat, Barcelona, SpainHospital Universitario Clínico San Carlos, Madrid, SpainHospital Da Costa, Burela, Lugo, SpainHospital del Mar, Barcelona, SpainHospital Universitario Virgen Macarena, Sevilla, SpainHospital Infanta Sofía, Madrid, SpainInstitut d'Assistència Sanitària (IAS) - Institut Català de la Salut, Girona, SpainHospital General Universitario de Elche, Elche, SpainFundación Hospital de Alcorcón, Madrid, SpainHospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, SpainComplejo Asistencial Universitario de Burgos, Burgos, SpainHospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, SpainHospital Universitario Ramón y Cajal, Madrid, SpainHospital Universitario Puerta de Hierro, Madrid, SpainHospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, SpainComplejo Hospitalario de Toledo, Toledo, SpainComplejo Hospitalario de Navarra, Pamplona, SpainCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Madrid, SpainHospital Universitario Central de Asturias, Oviedo, SpainComplejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, SpainHospital Universitario Donostia, San Sebastián, SpainHospital Arnau de Vilanova, Valencia, SpainHospital Ruber Internacional, Madrid, SpainHospital Universitario Vall d´Hebron, Barcelona, SpainHospital Universitario Lucus Augusti (HULA), Lugo, SpainHospital Rey Juan Carlos, Madrid, SpainComplejo Hospitalario Universitario de Orense (CHUO), Orense, SpainUnidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, SpainCIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), Madrid, SpainFundación Curemos el Parkinson, C/Juana de Vega 23 2°, A Coruña 15004, SpainIntroduction. In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient’s quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0–20; B: NMSS = 21–40; C: NMSS = 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p<0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p<0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p<0.0001). Conclusion. The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.http://dx.doi.org/10.1155/2021/8871549 |
| spellingShingle | D. Santos García T. De Deus Fonticoba J. M. Paz González C. Cores Bartolomé L. Valdés Aymerich J. G. Muñoz Enríquez E. Suárez S. Jesús M. Aguilar P. Pastor L. L. Planellas M. Cosgaya J. García Caldentey N. Caballol I. Legarda J. Hernández Vara I. Cabo L. López Manzanares I. González Aramburu M. A. Ávila Rivera M. J. Catalán V. Nogueira V. Puente J. M. García Moreno C. Borrué B. Solano Vila M. Álvarez Sauco L. Vela S. Escalante E. Cubo F. Carrillo Padilla J. C. Martínez Castrillo P. Sánchez Alonso M. G. Alonso Losada N. López Ariztegui I. Gastón J. Kulisevsky M. Blázquez Estrada M. Seijo J. Rúiz Martínez C. Valero M. Kurtis O. de Fábregues J. González Ardura C. Ordás L. López Díaz P. Mir P. Martinez-Martin COPPADIS Study Group Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life Parkinson's Disease |
| title | Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life |
| title_full | Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life |
| title_fullStr | Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life |
| title_full_unstemmed | Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life |
| title_short | Staging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life |
| title_sort | staging parkinson s disease combining motor and nonmotor symptoms correlates with disability and quality of life |
| url | http://dx.doi.org/10.1155/2021/8871549 |
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