Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats
The aim of the current study was to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARγ) agonists on cerebellar tissues oxidative damage in hypothyroid rats. The animals included seven groups: group I (control), the animals received drinking water; group II, the animal...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2016/1952561 |
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| author | Yousef Baghcheghi Farimah Beheshti Hossein Salmani Mohammad Soukhtanloo Mahmoud Hosseini |
| author_facet | Yousef Baghcheghi Farimah Beheshti Hossein Salmani Mohammad Soukhtanloo Mahmoud Hosseini |
| author_sort | Yousef Baghcheghi |
| collection | DOAJ |
| description | The aim of the current study was to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARγ) agonists on cerebellar tissues oxidative damage in hypothyroid rats. The animals included seven groups: group I (control), the animals received drinking water; group II, the animals received 0.05% propylthiouracil (PTU) in drinking water; besides PTU, the animals in groups III, IV, V, VI, and VII, were injected with 20 mg/kg vitamin E (Vit E), 10 or 20 mg/kg pioglitazone, and 2 or 4 mg/kg rosiglitazone, respectively. The animals were deeply anesthetized and the cerebellar tissues were removed for biochemical measurements. PTU administration reduced thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the cerebellar tissues while increasing malondialdehyde (MDA) and nitric oxide (NO) metabolites. Vit E, pioglitazone, and rosiglitazone increased thiol, SOD, and CAT in the cerebellar tissues while reducing MDA and NO metabolites. The results of present study showed that, similar to Vit E, both rosiglitazone and pioglitazone as PPARγ agonists exerted protective effects against cerebellar tissues oxidative damage in hypothyroid rats. |
| format | Article |
| id | doaj-art-59a0cfd32e7f42618e7c3f8780bcafe5 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-59a0cfd32e7f42618e7c3f8780bcafe52025-02-03T05:46:02ZengWileyNeurology Research International2090-18522090-18602016-01-01201610.1155/2016/19525611952561Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid RatsYousef Baghcheghi0Farimah Beheshti1Hossein Salmani2Mohammad Soukhtanloo3Mahmoud Hosseini4Student Research Committee, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeurocognitive Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeurogenic Inflammation Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeurocognitive Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranThe aim of the current study was to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARγ) agonists on cerebellar tissues oxidative damage in hypothyroid rats. The animals included seven groups: group I (control), the animals received drinking water; group II, the animals received 0.05% propylthiouracil (PTU) in drinking water; besides PTU, the animals in groups III, IV, V, VI, and VII, were injected with 20 mg/kg vitamin E (Vit E), 10 or 20 mg/kg pioglitazone, and 2 or 4 mg/kg rosiglitazone, respectively. The animals were deeply anesthetized and the cerebellar tissues were removed for biochemical measurements. PTU administration reduced thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the cerebellar tissues while increasing malondialdehyde (MDA) and nitric oxide (NO) metabolites. Vit E, pioglitazone, and rosiglitazone increased thiol, SOD, and CAT in the cerebellar tissues while reducing MDA and NO metabolites. The results of present study showed that, similar to Vit E, both rosiglitazone and pioglitazone as PPARγ agonists exerted protective effects against cerebellar tissues oxidative damage in hypothyroid rats.http://dx.doi.org/10.1155/2016/1952561 |
| spellingShingle | Yousef Baghcheghi Farimah Beheshti Hossein Salmani Mohammad Soukhtanloo Mahmoud Hosseini Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats Neurology Research International |
| title | Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats |
| title_full | Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats |
| title_fullStr | Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats |
| title_full_unstemmed | Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats |
| title_short | Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats |
| title_sort | protective effect of pparγ agonists on cerebellar tissues oxidative damage in hypothyroid rats |
| url | http://dx.doi.org/10.1155/2016/1952561 |
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