Environment as a Potential Key Determinant of the Continued Increase of Prostate Cancer Incidence in Martinique
Prostate cancer incidence is steadily increasing in many developed countries. Because insular populations present unique ethnic, geographical, and environmental characteristics, we analyzed the evolution of prostate cancer age-adjusted world standardized incidence rates in Martinique in comparison w...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/819010 |
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| _version_ | 1832551874198241280 |
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| author | Dominique Belpomme Philippe Irigaray |
| author_facet | Dominique Belpomme Philippe Irigaray |
| author_sort | Dominique Belpomme |
| collection | DOAJ |
| description | Prostate cancer incidence is steadily increasing in many developed countries. Because insular populations present unique ethnic, geographical, and environmental characteristics, we analyzed the evolution of prostate cancer age-adjusted world standardized incidence rates in Martinique in comparison with that of metropolitan France. We also compared prostate cancer incidence rates, and lifestyle-related and socioeconomic markers such as life expectancy, dietary energy, and fat supply and consumption, with those in other Caribbean islands, France, UK, Sweden, and USA. The incidence rate of prostate cancer in Martinique is one of the highest reported worldwide; it is continuously growing since 1985 in an exponential mode, and despite a similar screening detection process and lifestyle-related behaviour, it is constantly at a higher level than in metropolitan France. However, Caribbean populations that are genetically close to that of Martinique have generally much lower incidence of prostate cancer. We found no correlation between prostate cancer incidence rates, life expectancy, and diet westernization. Since the Caribbean African descent-associated genetic susceptibility factor would have remained constant during the 1980–2005, we suggest that in Martinique some environmental change including the intensive use of carcinogenic organochlorine pesticides might have occurred as key determinant of the persisting highly growing incidence of prostate cancer. |
| format | Article |
| id | doaj-art-599d265d82a446e08fd659a023fa5c50 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-599d265d82a446e08fd659a023fa5c502025-02-03T06:00:15ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/819010819010Environment as a Potential Key Determinant of the Continued Increase of Prostate Cancer Incidence in MartiniqueDominique Belpomme0Philippe Irigaray1Paris Descartes University, 75015 Paris, FranceClinical Cancer Research Department, European Cancer and Environment Research Institute (ECERI), 1000 Bruxelles, BelgiumProstate cancer incidence is steadily increasing in many developed countries. Because insular populations present unique ethnic, geographical, and environmental characteristics, we analyzed the evolution of prostate cancer age-adjusted world standardized incidence rates in Martinique in comparison with that of metropolitan France. We also compared prostate cancer incidence rates, and lifestyle-related and socioeconomic markers such as life expectancy, dietary energy, and fat supply and consumption, with those in other Caribbean islands, France, UK, Sweden, and USA. The incidence rate of prostate cancer in Martinique is one of the highest reported worldwide; it is continuously growing since 1985 in an exponential mode, and despite a similar screening detection process and lifestyle-related behaviour, it is constantly at a higher level than in metropolitan France. However, Caribbean populations that are genetically close to that of Martinique have generally much lower incidence of prostate cancer. We found no correlation between prostate cancer incidence rates, life expectancy, and diet westernization. Since the Caribbean African descent-associated genetic susceptibility factor would have remained constant during the 1980–2005, we suggest that in Martinique some environmental change including the intensive use of carcinogenic organochlorine pesticides might have occurred as key determinant of the persisting highly growing incidence of prostate cancer.http://dx.doi.org/10.1155/2011/819010 |
| spellingShingle | Dominique Belpomme Philippe Irigaray Environment as a Potential Key Determinant of the Continued Increase of Prostate Cancer Incidence in Martinique Prostate Cancer |
| title | Environment as a Potential Key Determinant of the Continued
Increase of Prostate Cancer Incidence in Martinique |
| title_full | Environment as a Potential Key Determinant of the Continued
Increase of Prostate Cancer Incidence in Martinique |
| title_fullStr | Environment as a Potential Key Determinant of the Continued
Increase of Prostate Cancer Incidence in Martinique |
| title_full_unstemmed | Environment as a Potential Key Determinant of the Continued
Increase of Prostate Cancer Incidence in Martinique |
| title_short | Environment as a Potential Key Determinant of the Continued
Increase of Prostate Cancer Incidence in Martinique |
| title_sort | environment as a potential key determinant of the continued increase of prostate cancer incidence in martinique |
| url | http://dx.doi.org/10.1155/2011/819010 |
| work_keys_str_mv | AT dominiquebelpomme environmentasapotentialkeydeterminantofthecontinuedincreaseofprostatecancerincidenceinmartinique AT philippeirigaray environmentasapotentialkeydeterminantofthecontinuedincreaseofprostatecancerincidenceinmartinique |