Discovery of novel and potent celastrol derivatives as PRDX1 inhibitors for cancer therapy through structure-based virtual screening

Discovery of novel and potent celastrol derivatives as PRDX1 inhibitors for cancer therapy through structure-based virtual screening

BackgroundPeroxiredoxin 1 (PRDX1) is an antioxidant enzyme overexpressed in several cancers that protects tumor cells from oxidative damage by scavenging excess reactive oxygen species making it a potential strategy for cancer therapy.MethodsIn this study, a multi-step screening strategy combining m...

Full description

Saved in:
Bibliographic Details
Main Authors: Lixia Guan, Yifei Geng, Yuting Wang, Miao-Miao Niu, Kun Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Prdx1
ROS
base-structure virtual screening
molecular docking
cancer cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1625604/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items