An overview of drug‐induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety

An overview of drug‐induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety

Abstract The human voltage‐gated sodium channel Nav1.5 (hNav1.5/SCN5A) plays a critical role in the initiation and propagation of action potentials in cardiac myocytes, and its modulation by various drugs has significant implications for cardiac safety. Drug‐dependent block of Nav1.5 current (INa) c...

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Main Authors: Khuram W. Chaudhary, Colleen E. Clancy, Pei‐Chi Yang, Jennifer B. Pierson, Alan L. Goldin, John E. Koerner, Todd A. Wisialowski, Jean‐Pierre Valentin, John P. Imredy, Armando Lagrutta, Simon Authier, Robert Kleiman, Philip T. Sager, Peter Hoffmann, Michael K. Pugsley
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.70098
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