Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome
BackgroundAlthough several studies linked the sugary beverages to chronic kidney disease (CKD), the role of different types of sugary beverages in the development of CKD remained inconsistent. This study aimed to examine the associations of sugar-sweetened beverages (SSBs), artificially-sweetened be...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1401081/full |
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| author | Xiao-Yu Dai Xiao-Yu Dai Xiang-Yu Chen Xiang-Yu Chen Li-Na Jia Xiao-Tong Jing Xiao-Yan Pan Xing-Yu Zhang Zhong Jing Jin-Qiu Yuan Jin-Qiu Yuan Qiang-Sheng He Qiang-Sheng He Li-Ling Yang |
| author_facet | Xiao-Yu Dai Xiao-Yu Dai Xiang-Yu Chen Xiang-Yu Chen Li-Na Jia Xiao-Tong Jing Xiao-Yan Pan Xing-Yu Zhang Zhong Jing Jin-Qiu Yuan Jin-Qiu Yuan Qiang-Sheng He Qiang-Sheng He Li-Ling Yang |
| author_sort | Xiao-Yu Dai |
| collection | DOAJ |
| description | BackgroundAlthough several studies linked the sugary beverages to chronic kidney disease (CKD), the role of different types of sugary beverages in the development of CKD remained inconsistent. This study aimed to examine the associations of sugar-sweetened beverages (SSBs), artificially-sweetened beverages (ASBs), and natural juices (NJs) with CKD risk, and assess the extent to which the associations were mediated through metabolic syndrome (MetS).MethodsThis is a prospective analysis of 191,956 participants from the UK Biobank. Participants with information on beverage consumption and no history of CKD at recruitment were included. Daily consumptions of SSBs, ASBs and NJs were measured via 24-h dietary recall. Cox models were fitted to calculate the hazard ratios (HRs) and confidence intervals (CIs) of sugary beverages intakes on CKD risk. The causal mediation analyses were conducted to investigate whether MetS explained the observed associations.ResultsWe documented 4,983 CKD cases over a median of 10.63 years follow-up. Higher consumption of SSBs and ASBs (>1 units/d compared with none) was associated with an elevated risk of CKD (HR: 1.45; 95% CI: 1.30–1.61, P-trend < 0.001 for SSBs and 1.52, 95% CI: 1.36–1.70 for ASBs). In contrast, we observed a J-shaped association between NJs and CKD with the with lowest risk at 0–1 unit/day (0–1 unit/d vs. 0, HR 0.86; 95% CI 0.81–0.91). The proportions of the observed association of higher intakes of SSBs and ASB with CKD mediated by MetS were 12.5 and 18.0%, respectively.ConclusionsHigher intakes of ASBs and SSBs were positively associated with the development of CKD, while moderate consumption of NJs was inversely associated with CKD risk. More intensified policy efforts are warranted to reduce intake of SSBs and ASBs for CKD prevention. |
| format | Article |
| id | doaj-art-59945844bbdc4afd96a4e7b11acac906 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-59945844bbdc4afd96a4e7b11acac9062024-11-26T04:26:48ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14010811401081Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndromeXiao-Yu Dai0Xiao-Yu Dai1Xiang-Yu Chen2Xiang-Yu Chen3Li-Na Jia4Xiao-Tong Jing5Xiao-Yan Pan6Xing-Yu Zhang7Zhong Jing8Jin-Qiu Yuan9Jin-Qiu Yuan10Qiang-Sheng He11Qiang-Sheng He12Li-Ling Yang13Department of Nephrology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaJiange People's Hospital, Jiange, Sichuan, ChinaDepartment of Nephrology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Nephrology, Meishan Second People's Hospital, Meishan, Sichuan, ChinaCentral Sterile Supply Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaSchool of Nursing, Wuhan University, Wuhan, ChinaDepartment of Nephrology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Nephrology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Nephrology, Mianyang 404 Hospital, Mianyang, ChinaClinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, ChinaScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, ChinaClinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, ChinaScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, ChinaDepartment of Nephrology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaBackgroundAlthough several studies linked the sugary beverages to chronic kidney disease (CKD), the role of different types of sugary beverages in the development of CKD remained inconsistent. This study aimed to examine the associations of sugar-sweetened beverages (SSBs), artificially-sweetened beverages (ASBs), and natural juices (NJs) with CKD risk, and assess the extent to which the associations were mediated through metabolic syndrome (MetS).MethodsThis is a prospective analysis of 191,956 participants from the UK Biobank. Participants with information on beverage consumption and no history of CKD at recruitment were included. Daily consumptions of SSBs, ASBs and NJs were measured via 24-h dietary recall. Cox models were fitted to calculate the hazard ratios (HRs) and confidence intervals (CIs) of sugary beverages intakes on CKD risk. The causal mediation analyses were conducted to investigate whether MetS explained the observed associations.ResultsWe documented 4,983 CKD cases over a median of 10.63 years follow-up. Higher consumption of SSBs and ASBs (>1 units/d compared with none) was associated with an elevated risk of CKD (HR: 1.45; 95% CI: 1.30–1.61, P-trend < 0.001 for SSBs and 1.52, 95% CI: 1.36–1.70 for ASBs). In contrast, we observed a J-shaped association between NJs and CKD with the with lowest risk at 0–1 unit/day (0–1 unit/d vs. 0, HR 0.86; 95% CI 0.81–0.91). The proportions of the observed association of higher intakes of SSBs and ASB with CKD mediated by MetS were 12.5 and 18.0%, respectively.ConclusionsHigher intakes of ASBs and SSBs were positively associated with the development of CKD, while moderate consumption of NJs was inversely associated with CKD risk. More intensified policy efforts are warranted to reduce intake of SSBs and ASBs for CKD prevention.https://www.frontiersin.org/articles/10.3389/fnut.2024.1401081/fullchronic kidney diseasesugar-sweetened beveragesartificially sweetened beveragesnatural juicesmediation analyses |
| spellingShingle | Xiao-Yu Dai Xiao-Yu Dai Xiang-Yu Chen Xiang-Yu Chen Li-Na Jia Xiao-Tong Jing Xiao-Yan Pan Xing-Yu Zhang Zhong Jing Jin-Qiu Yuan Jin-Qiu Yuan Qiang-Sheng He Qiang-Sheng He Li-Ling Yang Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome Frontiers in Nutrition chronic kidney disease sugar-sweetened beverages artificially sweetened beverages natural juices mediation analyses |
| title | Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome |
| title_full | Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome |
| title_fullStr | Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome |
| title_full_unstemmed | Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome |
| title_short | Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome |
| title_sort | sugary beverages intake and risk of chronic kidney disease the mediating role of metabolic syndrome |
| topic | chronic kidney disease sugar-sweetened beverages artificially sweetened beverages natural juices mediation analyses |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1401081/full |
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