Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules
This study was undertaken to evaluate the monocyte function of uraemic non-responders to hepatitis B vaccination. Therefore, some parameters concerning antigen processing by monocytes (Mo) as antigen presenting cells (APC) were analysed. It was found that in uraemic non-responders, (1) the internali...
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| Format: | Article |
| Language: | English |
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Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000093 |
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| author | J. Stachowski C. Barth M. Pollok J. Michalkiewicz K. Madalinski J. Maciejewski C. A. Baldamis |
| author_facet | J. Stachowski C. Barth M. Pollok J. Michalkiewicz K. Madalinski J. Maciejewski C. A. Baldamis |
| author_sort | J. Stachowski |
| collection | DOAJ |
| description | This study was undertaken to evaluate the monocyte function of uraemic non-responders to hepatitis B vaccination. Therefore, some parameters concerning antigen processing by monocytes (Mo) as antigen presenting cells (APC) were analysed. It was found that in uraemic non-responders, (1) the internalization of HBsAg by monocytes was significantly decreasjed—HBsAg complexed with specific IgG or as immune complex isolated from patients is better internalized compared with free HBsAg; (2) during antigen presentation the expression of adhesion (ICAM-1) and accessory (HLA-DR/Ia) molecules was significantly decreased in uraemic patients, especially in non-responders; and (3) impaired internalization of HBsAg as well as a decrease in ICAM-1 and HLA-DR/Ia expression, correlated well with the blunted proliferation of CD4+ T cells stimulated by autologous monocytes induced by HBsAg. |
| format | Article |
| id | doaj-art-59940f70e8fa4e29964c4b439cee0b0f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-59940f70e8fa4e29964c4b439cee0b0f2025-02-03T01:31:43ZengWileyMediators of Inflammation0962-93511466-18611995-01-0141495410.1155/S0962935195000093Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia moleculesJ. Stachowski0C. Barth1M. Pollok2J. Michalkiewicz3K. Madalinski4J. Maciejewski5C. A. Baldamis6Department of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyDepartment of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyDepartment of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyDepartment of Immunology, Children's Memorial Hospital, Warsaw, PolandDepartment of Immunology, Children's Memorial Hospital, Warsaw, PolandDepartment of Nephrology, 2nd Clinic of Children's Diseases, University School of Medical Sciences, Poznan, PolandDepartment of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyThis study was undertaken to evaluate the monocyte function of uraemic non-responders to hepatitis B vaccination. Therefore, some parameters concerning antigen processing by monocytes (Mo) as antigen presenting cells (APC) were analysed. It was found that in uraemic non-responders, (1) the internalization of HBsAg by monocytes was significantly decreasjed—HBsAg complexed with specific IgG or as immune complex isolated from patients is better internalized compared with free HBsAg; (2) during antigen presentation the expression of adhesion (ICAM-1) and accessory (HLA-DR/Ia) molecules was significantly decreased in uraemic patients, especially in non-responders; and (3) impaired internalization of HBsAg as well as a decrease in ICAM-1 and HLA-DR/Ia expression, correlated well with the blunted proliferation of CD4+ T cells stimulated by autologous monocytes induced by HBsAg.http://dx.doi.org/10.1155/S0962935195000093 |
| spellingShingle | J. Stachowski C. Barth M. Pollok J. Michalkiewicz K. Madalinski J. Maciejewski C. A. Baldamis Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules Mediators of Inflammation |
| title | Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules |
| title_full | Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules |
| title_fullStr | Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules |
| title_full_unstemmed | Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules |
| title_short | Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules |
| title_sort | defective antigen presentation by monocytes in esrd patients not responding to hepatitis b vaccination impaired hbsag internalization and expression of icam 1 and hla dr ia molecules |
| url | http://dx.doi.org/10.1155/S0962935195000093 |
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