Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules

This study was undertaken to evaluate the monocyte function of uraemic non-responders to hepatitis B vaccination. Therefore, some parameters concerning antigen processing by monocytes (Mo) as antigen presenting cells (APC) were analysed. It was found that in uraemic non-responders, (1) the internali...

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Main Authors: J. Stachowski, C. Barth, M. Pollok, J. Michalkiewicz, K. Madalinski, J. Maciejewski, C. A. Baldamis
Format: Article
Language:English
Published: Wiley 1995-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/S0962935195000093
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author J. Stachowski
C. Barth
M. Pollok
J. Michalkiewicz
K. Madalinski
J. Maciejewski
C. A. Baldamis
author_facet J. Stachowski
C. Barth
M. Pollok
J. Michalkiewicz
K. Madalinski
J. Maciejewski
C. A. Baldamis
author_sort J. Stachowski
collection DOAJ
description This study was undertaken to evaluate the monocyte function of uraemic non-responders to hepatitis B vaccination. Therefore, some parameters concerning antigen processing by monocytes (Mo) as antigen presenting cells (APC) were analysed. It was found that in uraemic non-responders, (1) the internalization of HBsAg by monocytes was significantly decreasjed—HBsAg complexed with specific IgG or as immune complex isolated from patients is better internalized compared with free HBsAg; (2) during antigen presentation the expression of adhesion (ICAM-1) and accessory (HLA-DR/Ia) molecules was significantly decreased in uraemic patients, especially in non-responders; and (3) impaired internalization of HBsAg as well as a decrease in ICAM-1 and HLA-DR/Ia expression, correlated well with the blunted proliferation of CD4+ T cells stimulated by autologous monocytes induced by HBsAg.
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publishDate 1995-01-01
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series Mediators of Inflammation
spelling doaj-art-59940f70e8fa4e29964c4b439cee0b0f2025-02-03T01:31:43ZengWileyMediators of Inflammation0962-93511466-18611995-01-0141495410.1155/S0962935195000093Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia moleculesJ. Stachowski0C. Barth1M. Pollok2J. Michalkiewicz3K. Madalinski4J. Maciejewski5C. A. Baldamis6Department of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyDepartment of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyDepartment of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyDepartment of Immunology, Children's Memorial Hospital, Warsaw, PolandDepartment of Immunology, Children's Memorial Hospital, Warsaw, PolandDepartment of Nephrology, 2nd Clinic of Children's Diseases, University School of Medical Sciences, Poznan, PolandDepartment of Nephrology, 5th Clinic of Internal Medicine, University of Cologne, GermanyThis study was undertaken to evaluate the monocyte function of uraemic non-responders to hepatitis B vaccination. Therefore, some parameters concerning antigen processing by monocytes (Mo) as antigen presenting cells (APC) were analysed. It was found that in uraemic non-responders, (1) the internalization of HBsAg by monocytes was significantly decreasjed—HBsAg complexed with specific IgG or as immune complex isolated from patients is better internalized compared with free HBsAg; (2) during antigen presentation the expression of adhesion (ICAM-1) and accessory (HLA-DR/Ia) molecules was significantly decreased in uraemic patients, especially in non-responders; and (3) impaired internalization of HBsAg as well as a decrease in ICAM-1 and HLA-DR/Ia expression, correlated well with the blunted proliferation of CD4+ T cells stimulated by autologous monocytes induced by HBsAg.http://dx.doi.org/10.1155/S0962935195000093
spellingShingle J. Stachowski
C. Barth
M. Pollok
J. Michalkiewicz
K. Madalinski
J. Maciejewski
C. A. Baldamis
Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules
Mediators of Inflammation
title Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules
title_full Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules
title_fullStr Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules
title_full_unstemmed Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules
title_short Defective antigen presentation by monocytes in ESRD patients not responding to hepatitis B vaccination: impaired HBsAg internalization and expression of ICAM-1 and HLA-DR/Ia molecules
title_sort defective antigen presentation by monocytes in esrd patients not responding to hepatitis b vaccination impaired hbsag internalization and expression of icam 1 and hla dr ia molecules
url http://dx.doi.org/10.1155/S0962935195000093
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